Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10604-6
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
Science
LASER couples damage sensing to ESCRT assembly for lysosome repair
Key Points
Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10604-6ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.