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Feedback Control of a Recirculating Bioreactor with Electrophoretic Removal of Inhibitory Extracellular DNA

arXiv CS Monday 01 June 2026, 04:00 UTC By Antonio Spallone, Davide Fiore, Fabrizio Carten\`i, Mario di Bernardo 1 min read
Key Points

arXiv:2603.23150v2 Announce Type: replace Abstract: Extracellular DNA accumulation in recirculating bioprocesses inhibits microbial growth and reduces productivity. We consider a continuous bioreactor with a recirculating loop and an electrophoretic filtration unit for selective DNA removal, and develop a feedback control framework combining online state and parameter estimation via an Unscented Kalman Filter with an adaptive Model Predictive Controller that jointly optimizes dilution rate...

arXiv:2603.23150v2 Announce Type: replace Abstract: Extracellular DNA accumulation in recirculating bioprocesses inhibits microbial growth and reduces productivity. We consider a continuous bioreactor with a recirculating loop and an electrophoretic filtration unit for selective DNA removal, and develop a feedback control framework combining online state and parameter estimation via an Unscented Kalman Filter with an adaptive Model Predictive Controller that jointly optimizes dilution rate and filtration activation. Closed-loop simulations under nominal and perturbed conditions show that the addition of the filtration unit enables the proposed control strategy to achieve significantly higher cumulative profit while keeping DNA concentration below the inhibition threshold.
Feedback Control (ORG) Unscented Kalman Filter (ORG)
Originally published by arXiv CS Read original →

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