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Querying Counterfactuals on Tissue Graphs with Supervised Disentanglement

arXiv:2606.08493v1 Announce Type: cross Abstract: \textit{Tissue graph counterfactuals} ask how a cell's expression would change under altered spatial neighbor contexts. Such queries are central to predicting cell behavior in tissues, but lack a unified definition, with existing methods targeting specific intervention types or treating cells as i.i.d. In this work, we first formalize \textit{tissue graph counterfactuals} as a class of spatial interventions that either rewire connections...

arXiv CS 1d ago