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Deep learning four decades of human migration
Abstract Human migration is a fundamental driver of global demographic change, shaping population structure, labour markets and social policy across countries1,2,3. Although long-term migration patterns are often linked to economic development4, they can shift rapidly in response to shocks such as conflict, environmental crises and political change5. Despite its importance, migration remains difficult to measure consistently: existing data are sparse, concentrated in high-income settings and...
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
Mitochondria directly interact with the nuclear pore complex
Abstract Mitochondria regulate cellular processes through direct and indirect interactions with other organelles. A well-studied example has been contact with the endoplasmic reticulum at mitochondrial-associated endoplasmic reticulum membranes1, which control pathways including redox and calcium homeostasis2,3. Recent studies have also reported direct mitochondria–nuclear membrane contacts in cancer cells and yeast that promote pro-survival signalling4,5.
Gene ancestries reveal diverse microbial associations during eukaryogenesis
Abstract The origin of eukaryotes remains a central enigma in biology1. Continuing debates agree on the pivotal role of a symbiosis between an alphaproteobacterium and an Asgard archaeon2,3. However, the nature, timing and contributions of other potential bacterial partners4,5,6 and the role of interactions with viruses7,8,9 remain contentious.
Amplified Arctic iceberg traffic reshapes benthic biodiversity
Abstract The Arctic is undergoing rapid warming, resulting in retreating sea ice and glaciers1, yet how cryospheric changes propagate into the deep ocean remains poorly understood2. Here we identify a climate-driven mechanism linking accelerating glacier disintegration to an increase in deep-sea hard-bottom habitats far beyond calving fronts. Seafloor observations in Fram Strait show a localized increase in the density and patchiness of dropstones delivered by debris-laden icebergs.
Nithya Raman to advance in L.A. mayoral runoff race, NBC News projects
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50 questions Nigel Farage 'must answer' over £5m 'gift' as he's urged to come clean
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Ranking college football's top 100 newcomers for t...
If the upcoming 2026 college football season is anything like its predecessor, transfer quarterbacks and top freshmen will be crucial for many College Football Playoff runs. And by now, with less than 100 days until the start of the season, we can assess rosters and what players did during spring practice with their new teams. While we have analyzed the top newcomer for each Power 4 team, these rankings are regardless of teams.
Can You Stop a Hypersonic Missile?
Can You Stop a Hypersonic Missile? The headlines say yes. Patriot crews shot down a Kinzhal over Kyiv on the night of May 4, 2023.
How back is the U? Can Clemson rebound? Previewing...
Life in the ACC certainly isn't boring. In the past year alone, the conference has produced a long and awkward CFP rankings battle, an irate affiliate member, a thrilling national title game run, the strangest tiebreaker result imaginable, an out-of-nowhere 11-win season, the most disappointing team in the country, an epic pro-to-college face-plant, 18 of the 38 best games of the 2025 season, the No. 1 pick in the NFL draft (indirectly) and the most awkward possible move to nine-game...