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Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
When Certainty Is Not Worth It: Capital Lock-Up and Settlement Discounting in Prediction Markets
Announce Type: new Abstract: Collateralized prediction markets are contingent-claim markets in which economic uncertainty can disappear before winning claims become redeemable. This paper studies the pricing effect of that delay. When collateral remains locked until oracle settlement, a near-certain dollar is a delayed dollar, so prices embed a maturity-dependent settlement discount in addition to beliefs about outcomes.
HD-DinoMoE: A Class-Aware Hierarchical Dual Mixture-of-Experts Network for Scleral Anomaly Segmentation in Complex Acquisition Scenarios
Announce Type: new Abstract: Traditional Chinese Medicine (TCM) ocular inspection provides empirical cues for assessing scleral surface anomalies, but its clinical use remains subjective and difficult to quantify. To support intelligent and quantifiable ocular inspection, this study presents the TCM-inspired Artificial Intelligence Ocular Auxiliary Diagnosis System (TAO) and focuses on pixel-level scleral surface anomaly segmentation. For clinical and user-acquired images affected by...
Big fleet expansion: Navy to add 4 made-in-India warships, one survey vessel this month
NEW DELHI: Indian Navy is set to witness significant expansion in its naval fleet this month as it gears up to induct five indigenously-built naval platforms, including two Project 17A stealth frigates, a survey vessel and two anti-submarine warfare crafts. The made-in-India vessels will enhance maritime security, combat readiness and coastal defence. The upcoming inductions also reflect on India's growing ability to design and construct sophisticated naval assets within the country,...