Acetylcholine
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Related Articles from SNS
Spontaneous and stimulus-driven arousal produce distinct acetylcholine dynamics across sensory and prefrontal cortex
Acetylcholine (ACh) release from the basal forebrain has traditionally been viewed as a slow, spatially diffuse signal regulating cortical arousal across sleep and wakefulness. Recent characterizations with higher resolution optical sensors have revealed rapid, local cholinergic modulation supporting dynamic changes in sensory processing, associative learning, and behavioral state. However, sensory events that recruit cortical ACh often also change arousal and evoke movements, making it...
Commensal-derived acetylcholine enhances mucosal immune education
Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10592-7A diet–microbiome–host axis strengthens mucosal immune defences and reinforces host–microbiota mutualism.
Arteriolar GMP signaling revealed by FRET-based real-time measurement in vivo
cGMP evokes arteriolar vasorelaxation and is generated in smooth muscle by the soluble guanylyl cyclase (sGC) stimulated by endothelial NO. Phosphodiesterases (PDEs) degrade cGMP and may contribute in diameter regulation. We examined arteriolar cGMP levels in real-time in vivo upon NO and acetylcholine (ACh) and effects of PDE inhibition.
Falls Induced by Optogenetic Inhibition of Basal Forebrain Cholinergic Projections after Dorsomedial Striatal Dopamine Depletion in a Dual Disruption Model of Falling Vulnerability in Parkinson Disease
Falls are a common and debilitating feature of Parkinson's Disease (PD) patients. Prefrontal acetylcholine (ACh) deficits, as well as nigrostriatal dopamine deficits, are implicated in vulnerability to falls. PD patients with loss of cortical ACh and associated cognitive dysfunction experience a higher rate of falls than PD patients without cortical ACh loss.
Scientists discover the brain chemical that helps you break bad habits
Scientists discover the brain chemical that helps you break bad habits Scientists have identified a brain chemical that appears to turn disappointment into a powerful trigger for change. - Date: - June 8, 2026 - Source: - Okinawa Institute of Science and Technology (OIST) Graduate University - Summary: - Scientists have uncovered a key brain signal that helps us break old habits and adapt when circumstances suddenly change.
Endothelium-Dependent Vasodilation is Impaired in Chronic Spinal Cord Injury and is Associated with Oxidative Stress
Background: Individuals with spinal cord injury (SCI) experience accelerated atherosclerotic cardiovascular disease that is not fully explained by traditional risk factors. Endothelial dysfunction is a key mechanism in atherosclerosis. We tested the hypothesis that endothelium-dependent vasodilation is impaired in adults with SCI and is due, at least in part, to oxidative stress.
Symptom Dimension-Specific Neurotransmitter Correlates of Psychopathology and Cognition in Early Psychosis
Extended duration of under-treated psychosis (DUP) is among the strongest predictors of poor outcome, yet diagnostic heterogeneity impedes treatment matching, with approximately 50% of patients failing to respond to first-line antipsychotics. Negative symptoms and cognitive impairment are particularly refractory, lacking effective pharmacological treatments. Identifying neurotransmitter systems associated with specific symptom dimensions could accelerate targeted therapeutic development and...
Early Alzheimer's signs 'often' include two changes — not memory loss
Early Alzheimer's signs 'often' include two changes — not memory loss In the early stages of Alzheimer's disease, the NHS says there are often signs to look out for - and these early dementia symptoms can appear before memory problems become noticeable In the earliest stages of Alzheimer's disease – the most common form of dementia – there are additional symptoms to look out for, beyond the well-known memory problems. It is worth understanding, however, how memory issues typically present in...