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High-avidity TCR signaling induces a distinct KLR-positive exhaustion state in human tumor-infiltrating CD8 T cells associated with immunotherapy response
Tumor-specific exhausted CD8 T cells (Tex) adopt diverse phenotypes across human cancers, but the drivers of this heterogeneity remain poorly understood. Using flow cytometry and single-cell RNA and T cell receptor (TCR) sequencing of 106,667 tumor-infiltrating CD8 T cells from head and neck squamous cell carcinoma (HNSCC) tumors, we identified and validated three Tex subsets, each with distinct clonotypes: (1) Tex-Conv, expressing conventional exhaustion genes; (2) Tex-CCR6, distinguished...
San Diego man survives encounter with grizzly bear at National Park
A San Diego man is recovering after surviving a grizzly bear attack while hiking in Montana’s Glacier National Park, an encounter he says he was fortunate to escape with his life. Daniel Crago, an avid outdoorsman, was hiking along the Grinnell Glacier Trail on May 28 during what was supposed to be the final day of a weeklong vacation filled with outdoor adventures. “My love for nature kind of started when I was young,” Crago said.
The best insoles for your sneakers
Do you have a job that requires you to be constantly on your feet? Or maybe you are an avid runner who logs long distances regularly? If you are often walking, running or standing, there’s a simple way to make your shoes more comfortable and supportive: add insoles to your running or walking sneakers.
Scathing House Judiciary Committee report accuses NFL of stretching law's limited antitrust exemption
A scathing report released on Monday by the House Judiciary Committee and its chairman Jim Jordan, takes the NFL to task, arguing that America's most popular sports league has ignored the narrow guardrails of the 1961 Sports Broadcasting Act and its antitrust exemption while on a journey to becoming a lucrative sports empire. All while limiting consumer choices and inflating prices for viewing games. The report, obtained by Fox News, includes the central argument on pages 8–9 that Congress...
As the Knicks chase history, Trump looks set to steal the spotlight
As the Knicks chase history, Trump looks set to steal the spotlight Donald Trump plans to be back at Madison Square Garden in New York to watch Game 3 of the NBA Finals between the Knicks and the San Antonio Spurs - Bookmark Donald Trump, once a familiar celebrity courtside at New York Knicks games, is set to make a rare return to his hometown as president, attending Game 3 of the NBA Finals. His presence stands in stark contrast to a bygone era, when he was famous but not yet defined by the...
The back-channel bid to go soft on Maduro
When Marco Rubio was named secretary of State, many in both South Florida Republican circles and the American energy industry exulted. But one man who bridged both worlds knew he had a problem. A longtime investor in Venezuela, the main source of crude oil needed to produce the asphalt that had made his family rich, Harry Sargeant III kept relations with top officials in Caracas even as they seized most foreign oil holdings.
Hoka Coupon Codes: 30% Off | June 2026
Hoka running shoes have been popular with trail and mountain runners (or “skyrunners”, if you prefer) since the company’s inception in 2009. But it was only during the Covid-19 pandemic that we all threw fashion out the window and became obsessed with these insanely puffy, comfy shoes. The iconic, everyday Cliftons are the most popular model, but we also like the Speedgoat series for trail running and the Anacapa hikers for more rugged terrain.
Rare bird sighting excites twitchers
feel good Rare black-headed gull sighting in Geraldton, WA Mon 8 Jun 2026 at 7:30am Twitchers have made their way to the coastal city of Geraldton in WA's Mid West after multiple sightings of a bird seen less than a dozen times in Australia. The black-headed gull usually migrates between Europe and Asia but this one is believed to have been blown off course in rough weather. Birdwatching friends Bill Betts and Daryl Jones were among dozens who travelled more than 400 kilometres from Perth to...
Enhancing Presence, Deepening Fan Intensity: How Presence in Immersive Video Shapes Psychological Closeness to Performers
Announce Type: new Abstract: Immersive video differs from conventional flat 2D video in that it is experienced as 180-degree stereoscopic video on a head-mounted display, thereby eliciting bodily and spatial subjective experience. Previous studies have shown that viewing and interpersonal distance affect Presence; however, it remains insufficiently understood how Presence differences are related to psychological closeness to content. In the present study, we examined whether differences in...
‘Backrooms’ Takes You Deeper Inside the Internet’s Most Uncanny Horror Myth
The 20-year-old filmmaker Kane Parsons has risen to the top so fast that he’s had zero time to process how far he’s come. “It's been go, go, go,” Parsons tells WIRED. “Even the tiniest bit of a break,” he says, would give him some better perspective on everything that’s happened over the past few years.