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Divide-Prompt-Refine: a Training-Free, Structure-Aware Framework for Biomedical Abstract Generation

Announce Type: replace Abstract: Biomedical abstracts play a critical role in downstream NLP applications, such as information retrieval, biocuration, and biomedical knowledge discovery. However, a non-trivial number of biomedical articles do not have abstracts, diminishing the utility of these articles for downstream tasks. We propose DPR-BAG (Divide, Prompt, and Refine for Biomedical Abstract Generation), a training-free, zero-shot framework that generates coherent and factually grounded...

arXiv CS 5d ago

Beyond Prompt-Based Planning: MCP-Native Graph Planning-based Biomedical Agent System

Announce Type: new Abstract: Biomedical agents promise to automate complex biological workflows, yet current systems face two fundamental bottlenecks: bioinformatics tools are highly heterogeneous in interfaces and execution environments, while agent planning still relies on flat prompt-retrieved tool descriptions. As biomedical software ecosystems grow, this coupling between tool coverage and context size leads to tool confusion, unstable planning, and inefficient execution. We introduce...

arXiv CS 6d ago

MMBU: A Massive Multi-modal Biomedical Understanding Benchmark to Probe the Perception Capabilities of Vision-Language Models

arXiv:2606.06696v1 Announce Type: new Abstract: Vision and language models (VLMs) hold immense promise to transform biomedical imaging workflows, from detecting lesions in chest X-rays to profiling cellular features in microscopy. Realizing this potential, however, requires robust and fine-grained visual perception. Models need to correctly interpret subtle features in images, and they must do so across diverse biomedical modalities, scales, and contexts.

arXiv CS 2d ago

A Web-based software toolkit for accessible and best-practice machine learning analyses in biomedical research

Machine learning is increasingly central to biomedical research, but using machine learning well often requires substantial computational expertise and methodological care to produce high-quality results. To make machinelearning tools more accessible to biomedical researchers while supporting best-practice approaches, we developed the Galaxy Learning and Modeling (GLEAM) software toolkit. GLEAM enables researchers to performsupervised machine learning analyses through a set of web-based,...

bioRxiv 3d ago

Beyond Agreement: Scoring Panel-Surfaced Biomedical Entity Candidates for Curator Triage

arXiv:2605.30826v1 Announce Type: new Abstract: Biomedical NER is deceptively simple for modern LLMs: plausible biomedical mentions are easy to surface, but corpus-convention correctness depends on annotation conventions, span boundaries, entity granularity, and type schemas. Multi-LLM agreement is a salience signal, not corpus-convention correctness. We introduce a candidate-level panel-output benchmark for panel-surfaced candidate verification, where the unit is an aligned candidate...

arXiv CS 9d ago

Protocol for evaluating ChatGPT in biomedical association generation and verification using a RAG-enabled, cross-model majority voting workflow

new Abstract: We present a protocol to evaluate ChatGPT's ability to generate disease-centric biomedical associations. It outlines how we generate the associations, validate the biological entities using biomedical ontologies, and verify associations using literature. The protocol includes a self-consistency strategy to assess generative reliability across ChatGPT models.

arXiv CS 9d ago

Forecasting novel therapeutic development in biomedical research

Early identification of promising drug research topics is challenging yet crucial for the scientific community to accelerate the development of novel therapeutics. In this work, we leverage large-scale public data from the biomedical literature to extract predictive features to identify promising therapeutic research topics at an early stage. We divide the global citation graph of biomedical literature into a time series of research topics and extract topic features based on citation...

bioRxiv 9d ago

Towards World Models in Biomedical Research

arXiv:2606.05925v1 Announce Type: new Abstract: A central goal of biomedicine is to understand, predict and ultimately control the dynamic mechanisms by which biological systems respond to perturbations, disease progression and therapeutic intervention. Although foundation models and large language models have accelerated biomedical data interpretation, most current systems remain focused on static pattern recognition rather than prospective simulation of biological futures. Here we propose...

arXiv CS 5d ago

Ignet 2.0 and Vignet: An Ontology-Driven Web Platform for Biomedical Gene Interaction Discovery and Visualization

Background: The expansion of biomedical literature demands systematic ontology-guided discovery of gene interactions, vaccine mechanisms, drug associations, and adverse events. Existing platforms such as STRING, DisGeNET, and PubTator fall short of providing a unified, freely accessible system that integrates ontology-based semantic interaction classification, vaccine-focused heterogeneous network construction, and Artificial Intelligence-assisted evidence retrieval. Ignet 2.0 and Vignet are...

bioRxiv 4d ago

Condition-Gated Reasoning for Context-Dependent Biomedical Question Answering

arXiv:2602.17911v3 Announce Type: replace Abstract: Current biomedical question answering (QA) systems often assume that medical knowledge applies uniformly, yet real-world clinical reasoning is inherently conditional: nearly every decision depends on patient-specific factors such as comorbidities and contraindications. Existing benchmarks do not evaluate such conditional reasoning, and retrieval-augmented or graph-based methods lack explicit mechanisms to ensure that retrieved knowledge is...

arXiv CS 1d ago