CA1 Forming
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Related Articles from SNS
Hippocampal CA2 modulates trace fear conditioning through circuit-specific control of CA1
Forming associations between temporally separated events depends on pathways linking the CA1, the subiculum (SUB), and the entorhinal cortex. The degree to which this process requires the CA2, which shares extensive connectivity with these regions, remains unknown. conditioning (TFC), where mice learn to associate a tone and shock separated by a temporal gap, we showed that the dCA2 contributes to TFC.
Differential vulnerability of CA1 pyramidal neuron cell types in the 5xFAD Alzheimer's disease mouse model
Selective neuronal vulnerability is a defining feature of Alzheimer's disease, yet how neurodegeneration unfolds across defined hippocampal CA1 pyramidal neuron populations remains unresolved. Previously, we showed that CA1 pyramidal neurons are organized into molecularly defined laminar cell types that form stable spatial signatures along the longitudinal axis (Pachicano et al., 2025). Here, we investigated how vulnerability manifests across CA1 pyramidal cell types in the 5xFAD mouse model...