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Binary Gaussian Copula Synthesis: an LLM-powered data augmentation framework for early dialysis prediction in chronic kidney disease

arXiv:2403.00965v2 Announce Type: replace-cross Abstract: Only a small fraction of patients with chronic kidney disease (CKD) progress to dialysis, creating severe class imbalance that limits the performance of machine learning models for early dialysis prediction. This challenge is compounded by the binary structure of electronic health record (EHR) data, for which most existing augmentation methods were not designed. We propose Binary Gaussian Copula Synthesis (BGCS), a two-stage data...

arXiv CS 5d ago

Applying Spatial Statistics to Spatial Transcriptomics Reveals Local Association Between M2-like Macrophages and Fibrosis in Diabetic Kidney Disease

Renal fibrosis is the common final pathway of chronic kidney disease (CKD), driven in part by myofibroblast-mediated extracellular matrix deposition. M2 macrophages have been implicated as a source of myofibroblasts through macrophage-to-myofibroblast transition (MMT), yet whether M2 macrophages are pro- or anti-fibrotic remains controversial, and the spatial context in which MAC-M2-fibrosis coupling occurs is unknown. Here, we applied geographically weighted regression (GWR), a spatial...

bioRxiv 7d ago

Doctors thought this kidney drug helped some patients. It may help millions more.

Doctors thought this kidney drug helped some patients. It may help millions more. - Date: - June 8, 2026

Science Daily 2d ago

First ever guidelines released to screen for condition that impacts 9 in 10 Americans

First ever guidelines released to screen for condition that impacts 9 in 10 Americans Doctors say earlier screening could help save lives - Bookmark - CommentsGo to comments Some 90 percent of Americans have at least one risk factor for cardiovascular-kidney-metabolic – or CKM – syndrome, a term for potentially life-threatening conditions that are all connected. Now, experts at the American Heart Association say more of the country should be screened for one particular risk factor in the...

The Independent World 16m ago