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Why diabetes matters in dementia studies. Excluding diabetes status masks regional mitochondrial DNA copy number changes in human hippocampus, amygdala, and cerebellum in Alzheimers disease
Diabetes is a major risk factor for Alzheimers disease (AD), and both diseases involve mitochondrial dysfunction. We hypothesised that AD is associated with reduced mitochondrial DNA copy number (mtDNA-CN) in vulnerable brain regions, and that diabetes modifies these changes. Post mortem hippocampus, amygdala, and cerebellum samples (N=66-77) from non cognitively impaired (NCI) and AD donors, with and without diabetes, were analysed.
China Crude Buying Seen Languishing for Months as Demand Tumbles
An oil tanker is docked unloading crude oil at the port in Qingdao, in China's eastern Shandong province, on April 7, 2026. (Photo by CN-STR / AFP via Getty Images) / China OUT
An Asynchronous Two-Speed Kalman Filter for Real-Time UUV Cooperative Navigation Under Acoustic Delays
arXiv:2604.02878v2 Announce Type: replace Abstract: In Global Navigation Satellite System (GNSS)-denied underwater environments, individual unmanned underwater vehicles (UUVs) suffer from unbounded dead-reckoning drift, making collaborative navigation (CN) crucial for accurate state estimation. However, the severe communication delay inherent in underwater acoustic channels poses serious challenges to real-time state estimation. Traditional filters, such as Extended Kalman Filters (EKFs) or...
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
Buildings lit up for baby with one-in-a-million illness
Buildings lit up for baby with one-in-a-million illness Buildings at 63 locations across Wales, the UK and Canada have been lit up in rainbow colours to mark the first birthday of a baby boy who suffers from a rare disorder which leads to frequent, life-threatening seizures. Rupert Smith, from Penymynydd in Flintshire, has a genetic neurological condition called Alternating Hemiplegia of Childhood (AHC), affecting about one child in a million. Dave Smith said he wanted to do something...
Graph-Guided Universum Learning in Generalized Eigenvalue Proximal SVMs for Alzheimer's Disease Classification
arXiv:2606.04699v1 Announce Type: new Abstract: Early and accurate detection of Alzheimer's disease (AD) is important for timely intervention and disease management. Generalized Eigenvalue Proximal Support Vector Machine (GEPSVM) and its Universum-based variants have shown promising results for AD classification. However, existing methods treat Universum samples as independent points and do not consider the geometric relationships among them.
High resolution spatial transcriptomics decodes the microenvironmental determinants of response to Nr-CWS therapy in cervical precancerous lesions
Immunotherapy with Nocardia rubra cell wall skeleton (Nr-CWS) can clear human papillomavirus (HPV) and induce regression of cervical precancerous lesions, yet many patients do not respond. The cellular and molecular basis for this heterogeneous clinical outcome remains unknown. Using high-resolution spatial transcriptomics, we profiled squamous intraepithelial lesions (SIL) from patients stratified by their subsequent response to Nr-CWS therapy.
Toronto: A travel guide to the 2026 World Cup host city
Canada's largest city will host six World Cup matches, including the co-host nation’s opening fixture. Canada's largest city will make history when it hosts the first men's FIFA World Cup match ever played on Canadian soil. Toronto welcomes six matches during the 2026 tournament at BMO Field, known as Toronto Stadium during the competition, including Canada's opening fixture.
Proteomic analysis of human leptomeningeal matrisome identifies changes in Alzheimer's disease
The leptomeninges (arachnoid and pia) are the inner layers of the meninges that envelope the brain. They define the borders of the subarachnoid space (SAS) where cerebrospinal fluid (CSF) circulates. Leptomeninges act as the barrier tissue and contribute to fluid exchange and immune function of the brain.
The Smart TV in Your LivingRoom Is a Node in the AIScraping Economy
The work at Include Security has us working with AI day in and day out (hacking it, using it, training it, etc). We’re all aware of the community-level opposition happening against datacenters, aimed at improving AI capabilities, being built recently. What you might not be aware of are the distributed efforts to train AI that could be using the devices inside your home.