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Related Articles from SNS
Enhanced glymphatic CSF tracer influx during α2-adrenergic agonist anesthesia is independent of tracer injection duration
The glymphatic system mediates brain-wide cerebrospinal fluid (CSF) transport and is highly sensitive to brain state. Experimental studies show that 2-adrenergic agonist based anesthesia enhances glymphatic CSF influx, whereas isoflurane markedly suppresses it. However, it has been suggested that the reduced tracer influx observed during isoflurane anesthesia may reflect rapid clearance of tracer from the basal cisterns rather than genuine inhibition of glymphatic transport.
FS-DVS: A Frequency-Selective Dynamic Visual Sensing Paradigm for Enhancing Information Completeness
arXiv:2606.06856v1 Announce Type: new Abstract: Dynamic vision sensors (DVS) offer exceptional temporal resolution and dynamic range by asynchronously reporting pixel-level intensity changes. However, conventional DVS rely on a per-pixel independent triggering mechanism, ignoring the spatial integration performed by biological retinal ganglion cells (RGCs). Consequently, they lack the contrast sensitivity function (CSF) and its inherent sensitivity to mid-spatial frequencies, which...
Proteomic analysis of human leptomeningeal matrisome identifies changes in Alzheimer's disease
The leptomeninges (arachnoid and pia) are the inner layers of the meninges that envelope the brain. They define the borders of the subarachnoid space (SAS) where cerebrospinal fluid (CSF) circulates. Leptomeninges act as the barrier tissue and contribute to fluid exchange and immune function of the brain.
Reconstructing and forecasting disease trajectories of patients with Alzheimer's disease using routine data in resource-constrained settings
arXiv:2606.07798v1 Announce Type: new Abstract: Alzheimer's disease is a progressive neurodegenerative disorder, and its progression varies substantially across patients. Existing work aims to forecast patients' future cognitive state, with minimal focus on reconstructing the state from past visits. Furthermore, in current research, quantifying predictive uncertainty remains underexplored and relies on costly modalities such as MRI, PET, and CSF, limiting their deployment in resource-limited...
CSFlow: Aligning Flow Matching with Human Contrast Sensitivity
arXiv:2606.08833v1 Announce Type: new Abstract: We introduce Contrast Sensitive Flow (CSFlow), a weighting scheme that connects the human eye's Contrast Sensitivity Function (CSF) to the iterative denoising steps of flow matching. Because real-world images concentrate signal at low spatial frequencies, these components reach high signal-to-noise ratio earlier during continuous diffusion than high-frequency components. When generating images with diffusion or flow matching models, this...
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Obstructive Sleep Apnea Syndrome Disrupts Glymphatic-Related Physiological Brain Pulsations
Background: Obstructive sleep apnea (OSA) affects over one billion people and increases neurodegenerative risk. Brain vasomotor, respiratory, and cardiac pulsations are thought to drive glymphatic clearance during sleep, yet OSA's effect on these pulsations remains poorly understood. Methods: We studied 20 healthy controls (HC; 39.7{+/-}8.0 y) and 12 patients with OSA (PWOSA; 53.0{+/-}11.0 y) using a four wavelength (690-980 nm) functional near-infrared spectroscopy (fNIRS) measuring...
Choriodecidual Ureaplasma parvum infection induces fetal lung inflammation prior to intra-amniotic infection in a nonhuman primate model
Preterm birth before 28 weeks remains a leading cause of neonatal mortality and long-term morbidity. Intrauterine infection-driven chorioamnionitis is strongly associated with preterm labor, fetal inflammatory response syndrome, and neonatal lung disease. Ureaplasma species are among the most common organisms isolated in chorioamnionitis and are frequently detected in the placenta, amniotic fluid, and respiratory tract of preterm infants.