CTB

A unified developmental framework of the human placenta in its uterine environment in vivo and in vitro

Despite advances in single-cell profiling of the human placenta, the genetic programs governing its physiological remodeling throughout gestation remain incompletely understood; this limits the interpretation of trophoblast organoid models. Here, we reconstruct the human placenta in its uterine environment across gestation by integrating public single-cell data into a unified developmental framework developed through a specialized computational strategy. We resolve 100 cell subtypes,...