Caenorhabditis
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Related Articles from SNS
The WormFood CURE: Screening for bioactive metabolites that antagonize the Caenorhabditis elegans Ras signaling pathway
Course-based Undergraduate Research Experiences (CUREs) provide an accessible, scalable platform for scientific discovery. Here, we present the WormFood CURE, which mines environmental bacterial isolates for bioactive secondary metabolites using Caenorhabditis elegans phenotype suppression as a functional readout. Utilizing the multivulva (Muv) phenotype, our pilot cohort interrogated 41 wild bacterial isolates for suppression of Ras/MAPK signaling.
Recombination and repetitive genomic landscapes are decoupled in a close relative of Caenorhabditis elegans
Genomes often exhibit heterogeneity across chromosomes, and distributions of protein-coding genes, repetitive elements, and polymorphisms are not uniform along chromosomes in multiple species. One explanation for these patterns is recombination rate variation. As recombination interacts with selection to shape the evolutionary fates of alleles, variation in recombination rate within and between chromosomes could promote differences in the distribution of genomic features across chromosomes.
Nutrient-responsive and DAF-16/FoxO target H1 histone HIL-1 promotes resistance to starvation and bacterial pathogens in Caenorhabditis elegans
Insulin/IGF-1 signaling (IIS) mediates metabolic and developmental acclimation to stressful conditions including starvation. The transcription factor DAF-16/FoxO actuates many of the physiological effects of reduced IIS, yet the specific contributions of DAF-16 target genes to stress resistance remain poorly understood. We explore the function of C. elegans H1 linker histone HIL-1/H1.0, a DAF-16 target that is upregulated during starvation.
In vivo functional classification of PTEN variants reveals context-dependent oncogenicity and interindividual variability
Gene variants, secondary mutations, and stochastic individual variability complicate cancer diagnosis, prognosis, and treatments. Here, we systematically assess the functional impact of PTEN cancer-related missense mutations in mammalian cell lines, yeast, and Caenorhabditis elegans. While cell-based assays revealed alterations in lipid phosphatase activity, CRISPR-based engineering of orthologous mutations in C. elegans enabled classification of variants based on organismal phenotypes and...
Constraining pesticide resistance using evolution-informed selection regimes
The rapid evolution of pesticide resistance in sexually reproducing pests threatens global food security, yet the evolutionary principles needed to design durable resistance management strategies remain poorly tested experimentally. Theory predicts that deploying multiple pesticide compounds simultaneously should suppress resistance more effectively than sequential rotations, but empirical support in sexual pest populations has remained inconclusive. Here, we directly test how selection...
Predicting and controlling nonlinear neuro-mechanical locomotion dynamics
arXiv:2605.03362v1 Announce Type: cross Abstract: Neuromechanics aims to understand the link between an animal's neural activity and its physical behaviors. Recent advances in experimental and machine learning techniques enable simultaneous recordings of neural and locomotion dynamics over long time periods and across multiple behavioral transitions in worms, flies, and other organisms. These high-dimensional datasets present the challenge of inferring interpretable low-dimensional dynamical...
Correcting for Global Synonymous Selection Improves the Accuracy of Episodic Positive Selection Inference
The ratio of nonsynonymous to synonymous substitution rates ({omega}) constitutes a fundamental parameter for inferring adaptive protein evolution, predicated upon the assumption that synonymous substitutions are selectively inert. This premise, however, is increasingly untenable given evidence of selection acting on synonymous substitutions, driven by various biological processes such as translational efficiency and mRNA stability. In this study, we demonstrate that unmodelled synonymous...
Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging
Proteostasis is essential for maintaining neuronal function, and its dysregulation is a hallmark of aging and neurodegeneration. The ubiquitin-proteasome system (UPS) and macroautophagy are the two major proteolytic pathways responsible for protein degradation. However, their capacity and regulation differ between cell types and across aging.