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Lignin to adipic acid in a high-yield chemical and biological redox process
Abstract Viable manufacturing pathways to produce bio-based chemicals from renewable feedstocks, such as lignin derived from plant biomass, are needed to decarbonize the chemicals manufacturing sector. Converting the recalcitrant lignin polymer to valuable bioproducts remains a longstanding challenge in biorefining, with the highest reported single-product yield from lignin currently around 20 wt% (refs. Most existing lignin depolymerization strategies target aryl–ether bond cleavage, which...
Laser beam builds cell-like protein networks without chemical modification
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Programmable chemistry unlocks drugs only in target cells, aiming to cut side effects
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Scientists found the hidden switch fueling alzheimer’s brain inflammation
Scientists found the hidden switch fueling alzheimer’s brain inflammation Scientists may have found a hidden Alzheimer’s “inflammation switch”—and turning it off protected brain connections in early studies. - Date: - May 31, 2026 - Source: - Scripps Research Institute - Summary: - Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically...
SIRT7 regulates dosage compensation and safeguards the female X chromosome
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Co-condensation and multivalency enable acetylation-sensitive, concentration-robust assembly of BRD4 condensates
Announce Type: new Abstract: Biomolecular condensates must assemble at specific locations and times inside living cells to perform their biological functions. However, it remains unclear how condensate formation achieves high spatiotemporal precision, responding sensitively to local chemical modifications while remaining robust to fluctuations in protein concentration. Here we study chromatin-associated BRD4 condensates to identify a physical mechanism that enables this combination of...
Chemists unlock first total synthesis of rare plant alkaloid tied to anticancer activity
Plants are undeniably one of nature's most promising sources of new medicines, with monoterpenoid indole alkaloids (MIAs) being a great example. Some intricate compounds are built from multiple-linked chemical units that form highly complex three-dimensional structures. Because of their size and shape, scientists believe such oligomeric MIAs may be able to interfere with specific protein–protein interactions inside cells—a biological target that conventional small-molecule drugs often...
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Synthesized peptides can slip into cells to block hard-to-target protein interactions
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Fast-moving droplets synthesize key drug compounds at room temperature, no catalysts needed
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