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Related Articles from SNS
UK’s stem cell transplant system may be putting lives at risk, report by MPs finds
System not fit for purpose due to poor infrastructure and planning, with minority groups particularly at risk, MPs sayThe UK’s stem cell transplant system is potentially putting the lives of blood cancer patients at risk as a result of inadequate infrastructure and a lack of long-term planning, a parliamentary report has found. A hematopoietic stem cell transplant, often referred to as a bone marrow transplant, is a medical procedure in which stem cells from a healthy donor are transplanted...
UK’s stem cell transplant system may be putting lives at risk, report by MPs finds
System not fit for purpose due to poor infrastructure and planning, with minority groups particularly at risk, MPs sayThe UK’s stem cell transplant system is potentially putting the lives of blood cancer patients at risk as a result of inadequate infrastructure and a lack of long-term planning, a parliamentary report has found. A hematopoietic stem cell transplant, often referred to as a bone marrow transplant, is a medical procedure in which stem cells from a healthy donor are transplanted...
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
New ways to prevent flu revealed in 'accidental' lab breakthrough, study finds
An accidental lab discovery has opened the door to entirely new ways of preventing the flu. While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported. By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.5 THINGS YOU NEED TO KNOW BEFORE GETTING YOUR FLU SHOT, ACCORDING...
Lysosomal lipid metabolism promotes tumor cell invasion through local energetics and membrane lipid remodeling
Metabolic vulnerabilities in cancer have been targeted primarily to suppress tumor growth, but less is known about the metabolic requirements for tumor cell invasion. Here we report that lipid catabolism by cytosolic and lysosomal lipases supports pancreatic cancer cell invasion through both overlapping and distinct functional and metabolic mechanisms. Lysosomal acid lipase (LAL)-dependent lipid droplet catabolism promotes invadopodia formation and stabilization, enabling extracellular...
Differential Induction of Cancer Cell Death by Root, Leaf, and Flower Extracts derived from Kalanchoe pinnata
Kalanchoe pinnata is a perennial plant that grows wild in tropical regions and is traditionally used as a medicinal plant. Plants of the Kalanchoe genus have been shown to possess several effects, including antibacterial and antihypertensive properties. However, effects such as the induction of apoptosis in cancer cells have not been reported for any substance other than leaf extracts of this plant and remain unexplained.
Woman's lies got innocent man arrested and held in police cell for seven hours
Woman's lies got innocent man arrested and held in police cell for seven hours Amelia Harrison, North Tyneside, Tyne and Wear, was "cagey" and asked a police officer to drop the case after police arrived at her home to continue their inquiries into the bizarre case A scheming woman's lies led an innocent man being arrested and held in a police cell. Amelia Harrison made a false report to police that the victim breached a court order by texting her, which led to him being held in custody when...
Leaf forces help steer stomata as young plants grow, experiments reveal
Leaf forces help steer stomata as young plants grow, experiments reveal Sadie Harley Scientific Editor Andrew Zinin Lead Editor Scientists have uncovered how the interplay between cell shape and mechanical stress influences the orientation of stomata (microscopic pores on the leaf surface) during early plant development. Stomata, from the Greek word for mouth, are essential gateways that regulate the exchange of carbon dioxide and oxygen, as well as water loss. The stomatal density and how...
Heterochromatin organization and liquid-liquid phase separation: it is not about if but about when
Heterochromatin is a membraneless compartment within the cell nucleus. In recent years, a controversy arose on whether heterochromatin organization is driven by liquid-liquid phase separation or not. While many heterochromatin proteins were shown to undergo liquid-liquid phase separation in vitro, other studies reported that this does not happen in cells.
Rational engineering of sdAb-based CAR T cells targeting BCMA enhances antitumor efficacy and persistence in Multiple Myeloma
BCMA-directed CAR T therapies have transformed the treatment of relapsed/refractory multiple myeloma (MM), yet durable responses remain limited by insufficient persistence and functional exhaustion. The contribution of antigen-binding domain properties to CAR T cell performance is not fully defined. Here, we report the rational discovery and engineering of BCMA-targeting single-domain antibodies (sdAbs) and their incorporation into second-generation CAR T cells.