Centromeres
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Related Articles from SNS
Centromeric footprints preserve telomere integrity in ALT cancers
Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10598-1Centromeric DNA repeat insertions and CENP-A chromatin assembly are identified as genomic signatures that preserve telomere integrity in ALT cancer cells.
Characterization of Human Ectocentromeric Sites.
Centromeres are composed of DNA repeats within chromosomes primary constriction. CENP-B is the only centromeric protein known to bind a specific motif, the CENP-B box, promoting kinetochore stability. We recently uncovered degenerate CENP-B binding motifs outside centromeres, whose position and orientation defines chromosome specific banding patterns.
Personalized reference genome-based pipeline reveals comprehensive haplotype-resolved views of cancer genomes
Cancer genome analysis relies on standard human reference genomes but detecting somatic alterations in highly repetitive or individual-specific regions remains challenging. We developed the Personalized Reference genome-based Cancer Genome Analysis Pipeline (PRCGAP), to our knowledge, the first comprehensive pipeline integrating haplotype-resolved analyses of somatic point mutations, structural variants, copy number, and DNA methylation on personalized diploid reference genomes. We applied...
Mitochondria directly interact with the nuclear pore complex
Abstract Mitochondria regulate cellular processes through direct and indirect interactions with other organelles. A well-studied example has been contact with the endoplasmic reticulum at mitochondrial-associated endoplasmic reticulum membranes1, which control pathways including redox and calcium homeostasis2,3. Recent studies have also reported direct mitochondria–nuclear membrane contacts in cancer cells and yeast that promote pro-survival signalling4,5.
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.
Extrachromosomal DNA as a Causal Instrument for Spatial Multi-Omics
Spatial transcriptomics, multiplex imaging, and computational pathology now map tissue organization at cellular resolution, but the analyses applied to these data remain correlational. Clustering and co-occurrence statistics describe which features appear together; they cannot say which feature drives the others. We propose a framework for causal inference in spatial multi-omics built on a specific feature of extrachromosomal DNA (ecDNA).