Chromatin
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Related Articles from SNS
Epigenome Alterations and 3D Chromatin Architecture Remodeling in Inflammatory Macrophage Activation under Diabetic Conditions
Aberrant monocyte and macrophage activation in diabetes drives chronic inflammation and complications. While epigenetic mechanisms are implicated, the role of 3D chromatin reorganization remains unclear. Using integrated multi-Omics, we profiled gene expression and 3D chromatin architecture in human CD14+ monocyte differentiated macrophages treated with high glucose plus TNF-alpha (HT) mimicking the diabetic milieu.
Fragmentation Patterns of Human Telomeric Chromatin in Plasma cfDNA
The unique chromatin structure at telomeres protects the linear ends of chromosomes from DNA surveillance machineries. Here, we demonstrate that circulating cell-free DNA (cfDNA) from plasma can map chromatin structure at telomeres. We find that the telomeric 6-mer repeats (TTAGGG/CCCTAA) are the most abundant circulating 6-mers in cfDNA.
Learning quality scores for chromatin accessibility bigWig tracks using Machine Learning
High-throughput chromatin accessibility assays such as bulk and single-cell ATAC-seq have generated large collections of processed signal tracks in bigWig format, which are widely used for visualisation, data integration, and Machine Learning (ML)-based analyses. Despite their central role, systematic quality control (QC) frameworks operating directly at the level of bigWig signal tracks remain underdeveloped. This gap limits the ability to assess data reliability and hampers robust...
Multi-omics analysis reveals chromatin and transcriptomic remodeling in hippocampal CA1 following adolescent social isolation
Social isolation (SI) during adolescence is associated with long-term vulnerability to psychiatric disorders; however, its effect on the hippocampal epigenome and transcriptome remains unclear. Here, we performed integrative ATAC-seq and RNA-seq of the hippocampal CA1 region using an adolescent mouse SI model, combined with single-cell RNA-seq reference mapping and cell type deconvolution. ATAC-seq identified SI-associated alterations in chromatin accessibility, including an increase in...
Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding
Nature, Published online: 08 June 2026; doi:10.1038/s41586-026-10738-7Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding
Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21
Correct neural progenitor cell (NPC) fate specification is essential to produce the full complement of neurons and glia needed for proper brain structure and function. Neurodevelopmental disorders, including the autosomal aneuploidy Down syndrome (DS), or Trisomy 21 (T21), are frequently associated with impaired cell fate decisions which ultimately drive differences in overall brain size and cell type composition through unknown mechanisms. To uncover mechanisms driving altered NPC fate in...
Histone succinylation directly inhibits Jumonji domain demethylases and stabilizes repressive chromatin states
Herein we uncover a relationship between histone succinylation and Jumonji (JmjC) domain-containing histone demethylases. We used quantitative proteomics and peptide pull-down assays to identify JmjC demethylases as candidate interactors with succinylated histone peptides. Succinyl-lysine peptides bind and inhibit the catalytic activity of JmjC demethylases in a dose-dependent manner.
Cooperative FOXA1-HNF4A binding emerges from motif spacing and nucleosome architecture
The pioneer factor hypothesis posits that specialized transcription factors access nucleosomal DNA to enable binding of secondary factors, implying a hierarchical mechanism of chromatin opening. However, recent evidence indicates that cooperative binding between pioneer and non-pioneer factors can occur in a context-dependent manner. Here we define the sequence and chromatin features that specify cooperative binding between FOXA1 and HNF4A. Using dual-induction of FOXA1 and HNF4A in naive...
Co-condensation and multivalency enable acetylation-sensitive, concentration-robust assembly of BRD4 condensates
Announce Type: new Abstract: Biomolecular condensates must assemble at specific locations and times inside living cells to perform their biological functions. However, it remains unclear how condensate formation achieves high spatiotemporal precision, responding sensitively to local chemical modifications while remaining robust to fluctuations in protein concentration. Here we study chromatin-associated BRD4 condensates to identify a physical mechanism that enables this combination of...
Cell-specific regulatory circuits connect genetic variation to disease susceptibility
Genome-wide association studies have identified thousands of variants associated with immune-related diseases, yet most lie in non-coding regions, complicating mechanistic interpretation. Regulatory quantitative trait loci (QTLs), such as expression QTLs (eQTLs) and chromatin accessibility QTLs (caQTLs), offer a powerful framework for prioritization and interpretation of these disease-associated genetic variants. When analyzed together, they offer deeper insights into the regulatory...