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Related Articles from SNS
Fasting Status and Epigenetic Clock Stability: Implications for Aging Research
Background: Epigenetic clocks are DNA methylation-based biomarkers increasingly used in aging research and clinical trials. A recent assessment of 18 clocks across multiple short-term perturbations concluded that most demonstrate only moderate biological reliability, raising concerns about their translational utility. However, understanding biological variability requires understanding the construction of each clock: different clocks capture distinct biological properties that respond...
A thorium-229 optical nuclear clock with feedback loop
Announce Type: replace Abstract: The laser-accessible nuclear transition in the thorium-229 isotope has been identified as a promising candidate for the realization of an optical nuclear clock. Such a nuclear clock might rival or outperform current optical clocks based on electron-shell transitions in atoms or ions, is expected to be more robust against external perturbations, and provides enhanced sensitivity in clock-based tests of fundamental principles of physics. Here, we implement a...
A thorium-229 optical nuclear clock with feedback loop
Announce Type: new Abstract: The laser-accessible nuclear transition in the thorium-229 isotope has been identified as a promising candidate for the realization of an optical nuclear clock. Such a nuclear clock might rival or outperform current optical clocks based on electron-shell transitions in atoms or ions, is expected to be more robust against external perturbations, and provides enhanced sensitivity in clock-based tests of fundamental principles of physics. Here, we implement a...
Scientists discover the master clock that controls biological growth and development
Scientists discover the master clock that controls biological growth and development - Date: - June 4, 2026 - Source: - Cold Spring Harbor Laboratory - Summary: - A newly discovered genetic clock acts as the master timekeeper for development, orchestrating crucial bursts of gene activity throughout a worm’s growth. When the clock is disrupted, development stops, offering fresh clues about how growth-related disorders may arise. - Share: Imagine a train sitting at a station.
A nuclear clock based on $^{229}$Th
Announce Type: new Abstract: Atomic clocks have made time and frequency the most precisely measured quantities in physics, progressing from microwave standards that realize the SI second to optical clocks that now reach unprecedented levels of precision. A nuclear clock would shift the frequency reference from an electronic transition to the uniquely low-lying, laser-accessible isomeric transition in the $^{229}$Th nucleus, offering a route to compact, robust timekeeping and sensitive tests...
Comparing sliding-mode, bang-bang and linear-quadratic-Gaussian for steering an atomic clock
arXiv:2605.20156v2 Announce Type: replace Abstract: Accurate timekeeping relies on feedback that continually steers a local clock toward a higher-grade reference. We evaluate first-order sliding-mode control (SMC) for steering an atomic clock and benchmark it against two standards: linear-quadratic-Gaussian (LQG) control and the bang-bang (BB). All three are tested in a common numerical framework using the standard two-state clock model driven by white and random-walk-frequency noise.
Cell-type targeted CRISPR/Cas9 Clock knockdown in mouse VTA dopamine neurons alter sleep, behavior, and cellular excitability
Bipolar disorder (BD) is a severe psychiatric disease characterized by recurrent mania, depression, and circadian rhythm disruption. Among circadian regulators implicated in mood-related dysfunction, Clock has emerged as a particularly strong mechanistic candidate. However, cell type-specific functions of Clock within mood-relevant circuits remain incompletely defined.
CTS-Bench: Benchmarking Graph Coarsening Trade-offs for GNNs in Clock Tree Synthesis
arXiv:2602.19330v2 Announce Type: replace Abstract: Graph Neural Networks (GNNs) are increasingly explored for physical design analysis in Electronic Design Automation, particularly for modeling Clock Tree Synthesis behavior such as clock skew and buffering complexity. However, practical deployment remains limited due to the prohibitive memory and runtime cost of operating on raw gate-level netlists. Graph coarsening is commonly used to improve scalability, yet its impact on CTS-critical...
Ultrafast laser shrinks to chip scale, potentially lowering costs for diagnostics and atomic clocks
Ultrafast laser shrinks to chip scale, potentially lowering costs for diagnostics and atomic clocks Stephanie Baum Scientific Editor Robert Egan Associate Editor Ultrafast lasers emit pulses lasting only a few hundred femtoseconds (quadrillionths of a second). These flashes of light power applications from precision micromachining to eye surgery to optical frequency combs, the Nobel Prize-winning technology behind today's most precise optical atomic clocks. Yet despite more than two decades...
Round-the-clock help for terror attack victims announced in victory for families
EXCLUSIVE: Round-the-clock help for terror attack victims announced in victory for families Security minister Dan Jarvis told The Mirror that the fragmented and complex system for survivors and grieving families to get support following terror attacks 'ends now' Bereaved families and survivors of terror attacks will finally be given around-the-clock support in a major victory for victims. Home Office minister Dan Jarvis told The Mirror that the complex and fragmented system for getting help...