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Powering up a module from the IBM 604: an electronic calculator from 1948

1948 was an interesting time for computing. For decades, businesses had used punch card equipment that added and sorted electromechanically. Now these electromechanical relays and counting wheels were being used to build room-filling general-purpose computers such as Harvard Mark I (1944) and IBM's SSEC (1948).

Hacker News 3d ago

Light-induced quantum friction of carbon nanotubes in water

Abstract Friction slows down moving objects at both macroscopic and microscopic scales1. At the electronic level, quantum friction describes direct transfer of momentum between a liquid and the electrons of a solid2. Owing to its microscopic nature, this phenomenon remains experimentally challenging to capture3.

Nature 20h ago

Brume is a 24-voice multi-timbral desktop synth for the CM5

FM Six operators across twelve algorithm topologies, per-op ratio and level, global feedback, a per-voice FM-index envelope, and a voice-tail state-variable filter with its own envelope — DX-style FM with subtractive shaping on the way out. A desktop multi-timbral music machine with four synthesis engines, a 10″ touch surface, and one cable to your DAW. Brume runs four synthesis engines with a shared voice tail (state-variable filter, amp envelope, modulation router), so patches stay...

Hacker News 7d ago

BMCR: Adaptive Backbone Module Composition via Reinforcement Learning for Remote Sensing Object Detection

arXiv:2606.05586v1 Announce Type: new Abstract: In remote sensing object detection, Convolutional Neural Networks (CNNs) excel at capturing local details while Vision Transformers (ViTs) are better at global context modeling. However, existing detectors typically rely on a single fixed backbone or a manually designed hybrid architecture, and thus fail to adaptively exploit these complementary strengths across inputs of diverse complexity.

arXiv CS 5d ago

STITCH: Spatial Transcriptomics Imputation via Flow Matching with Internal Learning

Spatial transcriptomics datasets frequently suffer from spatial gaps and missing regions due to sectioning artifacts, tissue damage, and the high cost of sequencing that limits tissue coverage. We present STITCH, a scalable and robust generative framework for multidimensional virtual spatial transcriptomics reconstruction. STITCH models intrinsic spatial-transcriptomic patterns directly from individual tissue samples, enabling reconstruction without requiring external reference atlases or...

bioRxiv 4d ago

Did this star eat its planets? A new study offers clues on 'chemical paradox' of a binary system

June 5, 2026 report Did this star eat its planets? A new study offers clues on 'chemical paradox' of a binary system Shreejaya Karantha Author Lisa Lock Scientific Editor Robert Egan Associate Editor Astronomers have investigated a puzzling binary star system in which two stars that may have formed together now show dramatically different chemical compositions.

Phys.org 5d ago

Ahoy, DECmate II the little PDP-8 that could

Now, that's a lot of word processing. But under the hood it's still at least PDP-8 adjacent, even considering its oddities and incompatibilities, and you can make it do many of the things a full-size Eight can. We'll take this basic unit, convert the floppy drives to solid state, tap the video output, and put it through its paces.

Hacker News 10d ago

PlayStation Architecture

Supporting imagery A quick introduction Sony knew that 3D hardware could get very messy to develop for. Thus, their debuting console will keep its design simple and practical… Although this may come at a cost!

Hacker News 7d ago

Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer

Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.

Nature 20h ago

A prognostic human brain network for diffuse midline glioma

Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.

Nature 20h ago