DMM
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Dynamic Meta-Metrics: Source-Sentence Conditioned Weighting for MT Evaluation
arXiv:2605.09098v2 Announce Type: replace Abstract: We propose Dynamic Meta-Metrics (DMM), a framework for machine translation evaluation that learns source-sentence conditioned combinations of existing metrics. Rather than relying on a single static ensemble or language-specific weighting, DMM adapts the metric combination based on properties of the source segment. We study hard conditioning, which fits an interpretable combiner per cluster, and an exploratory soft-conditioned extension...
Leptin Drives Osteoarthritis Pain Through Sensory Neuron Reprogramming Independent of Cartilage Signaling
Objective: Pain in osteoarthritis (OA) is often discordant with structural joint damage, particularly in obesity-associated OA, where adipose-derived signals may drive nociception independently of cartilage pathology. Leptin has been demonstrated to be necessary, but not sufficient, to drive obesity-associated OA. Here, we tested the hypothesis that leptin mediates OA-associated pain through sensory neuron reprogramming rather than chondrocyte-intrinsic signaling, suggesting a fat-sensory...
Systematic Engineering of Intra-Articular Drug Release Profiles Reveals a Key Determinant of Disease-Modifying Efficacy in Post-Traumatic Osteoarthritis
Post-traumatic osteoarthritis (PTOA) is a progressive joint disease for which no disease-modifying osteoarthritis drugs (DMOADs) have been approved. Although injectable drug delivery systems can prolong therapeutic retention within the joint, it remains unclear whether local drug release kinetics influence disease-modifying efficacy. Here, we developed a modular platform of injectable supramolecular hydrogels using biocompatible, generally recognized as safe (GRAS) amphiphilic molecules and...