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Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
AKIP1 is an inner scaffold component required for centriole integrity
Centrioles are microtubule-based organelles that play crucial roles in various biological processes, including cell division, ciliogenesis and flagellar assembly. These functions require the preservation of centriole structural integrity, yet the molecular mechanisms that maintain this integrity remain incompletely understood. In this study, through large-scale gene co-dependency analysis and ultrastructure expansion microscopy (U-ExM), we identified A-kinase interacting protein 1 (AKIP1) as...