Developmental Progression
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Related Articles from SNS
A C-terminal Processing Protease Implicated in Flagellin Turnover and Developmental Progression in a Bacterial Predator
Carboxy-terminal processing proteases (CTPs) are widely conserved bacterial proteases implicated in protein maturation, quality control, and stress responses, yet many family members functions remain unclear. Here, we characterise Bd0967, a previously unstudied CTP from the predatory bacterium Bdellovibrio bacteriovorus, and its role in flagellar function during predatory development. Crystal structures reveal a self-compartmentalised protease in which a PDZ domain forms a lid over a large...
Beyond Tool Adoption: A Practical Five-Stage Developmental Continuum for AI Literacy in Higher Education
arXiv:2606.00038v2 Announce Type: replace Abstract: We propose a five-stage AI Literacy Continuum for higher education consisting of Not Yet Engaged, Uncritical Use, Informed Use, Critical Evaluation, and Improvement. The continuum addresses a gap in existing AI literacy frameworks, which define competencies but provide limited guidance for diagnosing learner starting points and developmental progression. Drawing on design-based implementation across credit-bearing courses and intensive...
Scientists discover the master clock that controls biological growth and development
Scientists discover the master clock that controls biological growth and development - Date: - June 4, 2026 - Source: - Cold Spring Harbor Laboratory - Summary: - A newly discovered genetic clock acts as the master timekeeper for development, orchestrating crucial bursts of gene activity throughout a worm’s growth. When the clock is disrupted, development stops, offering fresh clues about how growth-related disorders may arise. - Share: Imagine a train sitting at a station.
First nonrepeating biological clock discovered in C. elegans guides growth
First nonrepeating biological clock discovered in C. elegans guides growth Andrew Zinin Lead Editor Imagine a train parked at the station. Passengers climb aboard and find their seats. Conductors move up and down the aisles, checking tickets.
Concerns NDIS cuts could create increase domestic violence risks
NDIS cuts could create unsafe environments and domestic violence risks, inquiry warned Wed 10 Jun 2026 at 1:29pm In short: The second day of public hearings into the government's generational NDIS changes has kicked off in Canberra. The inquiry heard concerns the proposed changes could create a number of unintended consequences that would disproportionately affect women. The government says it is monitoring the inquiry and maintains the NDIS needs a structural reset to keep it sustainable...
Test-Time Scaling in Multimodal Foundation Models: A Comprehensive Survey of Generation and Reasoning
arXiv:2606.08231v1 Announce Type: new Abstract: Test-time Scaling (TTS) has emerged as a pivotal research direction for enhancing model performance by dynamically allocating computational resources during inference. Recent advancements have adapted this paradigm to Multimodal Foundation Models (MFMs), unlocking their potential in multimodal reasoning and generation. Despite rapid progress, the field lacks a systematic survey and unified theoretical framework to delineate the developmental...
Development positions malignant cellular states but does notexplain their diversification
Epithelial cancers are often described as aberrant reactivations of embryonic or tissue-forming programs, but whether malignant cellular-state diversification is actually constrained by developmental trajectories remains unclear. Here, we present a quantitative framework to test this idea in pancreatic ductal adenocarcinoma (PDAC). Using representation learning on large-scale single-cell data, we build a reference space that captures the main axes of normal foregut and pancreatic epithelial...
Information Geometry of Intracellular Compartment Coupling Reveals Transcriptomic State Transitions in Single Cells
Single-cell transcriptomic analyses typically characterize cellular states using gene-expression variability, dimensionality reduction, and trajectory inference. However, existing approaches provide limited insight into how transcriptomic information is organized across interacting intracellular compartments. Here we introduce Compartment Coupling Entropy (CCE), an information-geometric framework that quantifies the organization of transcriptomic coupling between spliced and unspliced RNA...
A unified developmental framework of the human placenta in its uterine environment in vivo and in vitro
Despite advances in single-cell profiling of the human placenta, the genetic programs governing its physiological remodeling throughout gestation remain incompletely understood; this limits the interpretation of trophoblast organoid models. Here, we reconstruct the human placenta in its uterine environment across gestation by integrating public single-cell data into a unified developmental framework developed through a specialized computational strategy. We resolve 100 cell subtypes,...
Advances in supporting development in autistic children and youth
AbstractAutism is a neurodevelopmental condition with varied trajectories through the lifespan, leading to individualized patterns of strengths and challenges. Longitudinal autism cohort studies show the importance of developmental and adaptive skills starting in the early years, followed by emerging co-occurring conditions, and opportunities for autonomy and community participation when approaching adulthood. Studies of interventions to support developmental outcomes in autistic children...