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Rapid Determination of Drug-to-Antibody Ratios in Antibody Drug Conjugates Using Ultrafast Microdroplet Digestion Technology
Accurate determination of drug to antibody ratios (DARs) is essential for the development, quality control, and performance evaluation of antibody drug conjugates (ADCs); yet conventional analytical approaches often require extensive sample preparation, long analysis time, and substantial sample consumption. The peak distribution of intact ADCs is highly complex due to inherent glycosylation heterogeneity and variable drug conjugation. By applying enzymatic digestion, ADC can be converted...
Despite killing 200 people in attacks on suspected drug boats, US has done little to slow drug trade, experts say
Despite killing 200 people in attacks on suspected drug boats, the US has done little to slow the drug trade, experts say. The attacks, which have been carried out by the US Coast Guard and other agencies, have not made a significant impact on cocaine availability in the US. Researchers say that the attacks have not been effective in reducing the supply of cocaine, and that the US needs to take a more comprehensive approach to addressing the drug trade.
Pharmacist warns of shortage of 188 common NHS drugs - full list
Pharmacist warns of shortage of 188 common NHS drugs - full list Pharmacist says NHS drugs shortage is the 'worst' he's known as supply issues hit dozens of common medications A pharmacist has warned that the current drugs shortage is the 'worst I've ever known' as supply problems affect dozens of everyday medicines. Some drugs used to treat conditions ranging from high blood pressure to diabetes are running low, with certain patients reportedly struggling to obtain their regular...
Drug use in ethnic minority groups: a review and recommendations
Drug use in ethnic minority groups: a review and recommendations This report reviews drug use in ethnic minority groups and outlines recommendations for further data collection. Documents Details The Advisory Council on the Misuse of Drugs (ACMD) has produced this report to: - review the challenges facing the reporting of drug use in ethnic minority groups - consider the effects of substance use in these groups - consider the accessibility and barriers to current treatment services and...
Ovarian cancer: What is the new drug approved for the NHS in England?
A new drug to treat resistant ovarian cancer, and the first to be approved in over two decades, has been approved for patients in the NHS in England. What is the new drug?Mirvetuximab soravtansine (marketed as Elahere), developed by AbbVie, is an advanced, targeted treatment that combines a “homing” antibody with a cancer destroying drug. Often described by scientists as a “biological missile” or “trojan horse” therapy, the drug is already available in the US and Europe.
Some drugs 'fail' because of unrealistic testing conditions, scientists discover
Some drugs 'fail' because of unrealistic testing conditions, scientists discover Sadie Harley Scientific Editor Robert Egan Associate Editor A drug once dismissed as ineffective suddenly worked—when scientists tested it under more realistic conditions that mimic the human body. In this surprising new discovery, Northwestern University scientists uncovered a hidden rule of drug behavior. A medicine's effectiveness can change dramatically depending on the conditions inside our cells.
Nanoparticles boost delivery of lung cancer drugs 30-fold
Nanoparticles boost delivery of lung cancer drugs 30-fold Lisa Lock Scientific Editor Robert Egan Associate Editor Lung cancer remains one of the world's deadliest cancers, yet despite decades of effort to develop new drugs, many fail because they don't stay in the body long enough to be effective or because they damage healthy organs. Now, Adelaide University researchers have developed a novel nanoparticle "delivery vehicle" that precisely targets cancer drugs to the lungs while helping to...
Ozempic and similar weight-loss drugs linked to 30% lower breast cancer risk
Ozempic and similar weight-loss drugs linked to 30% lower breast cancer risk Popular GLP-1 weight-loss drugs may have an unexpected bonus: a significantly lower risk of breast cancer. - Date: - June 6, 2026 - Source: - University of Pennsylvania School of Medicine - Summary: - A large study found that women taking GLP-1 drugs, the medication class behind Ozempic, Wegovy, Mounjaro, and Zepbound, were about 30% less likely to develop breast cancer.
Life-saving breast cancer and endometriosis drug to be discontinued
AstraZeneca pulls critical breast cancer and endometriosis drug Zoladex from shelves Thu 4 Jun 2026 at 4:49am In short: AstraZeneca has announced it will pull a critical breast cancer and endometriosis drug from Australian shelves from November. Patients have labelled the decision "cruel" and say they have been blindsided. AstraZeneca says it will provide free access to the drug for six months for those without alternative treatment pathways.
Researchers discover how to turn one germ's drug resistance into an Achilles' heel
Researchers discover how to turn one germ's drug resistance into an Achilles' heel Lisa Lock Scientific Editor Andrew Zinin Lead Editor Decades of reliance on the antibiotic rifampicin have fueled the rise of drug-resistant Mycobacterium tuberculosis (Mtb). But as the bacterium mutates to protect itself from the drug, it also creates new weak points that other therapies could exploit. Now, a new study published in Nature Microbiology shows that the most common rifampicin-resistance mutation...