Epigenome Alterations
No mentions found
This entity hasn't been tracked yet, or Iris is still building its knowledge base.
Related Articles from SNS
Epigenome Alterations and 3D Chromatin Architecture Remodeling in Inflammatory Macrophage Activation under Diabetic Conditions
Aberrant monocyte and macrophage activation in diabetes drives chronic inflammation and complications. While epigenetic mechanisms are implicated, the role of 3D chromatin reorganization remains unclear. Using integrated multi-Omics, we profiled gene expression and 3D chromatin architecture in human CD14+ monocyte differentiated macrophages treated with high glucose plus TNF-alpha (HT) mimicking the diabetic milieu.
Epigenetic Profiling of Human Insulinomas Reveals AP-1 Family as Critical Regulators of Beta Cell Maturation
Insulinomas are rare and benign human pancreatic adenomas that overproduce insulin and display increased beta cell mass. We and others have shown that transcriptomic and genomic profiling on insulinomas provides a data mine for identifying targets that can be manipulated to induce human beta cell regeneration. Majority of causative genetic variants in insulinomas involve epigenetic regulatory genes.
Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21
Correct neural progenitor cell (NPC) fate specification is essential to produce the full complement of neurons and glia needed for proper brain structure and function. Neurodevelopmental disorders, including the autosomal aneuploidy Down syndrome (DS), or Trisomy 21 (T21), are frequently associated with impaired cell fate decisions which ultimately drive differences in overall brain size and cell type composition through unknown mechanisms. To uncover mechanisms driving altered NPC fate in...
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features
Cancer arises from extensive genetic and epigenetic alterations that reshape chromatin, transcriptional regulation, and malignant cell states. To systematically chart cancer-intrinsic regulatory programs, we constructed a pan-cancer single-cell transcriptomic and epigenomic atlas encompassing 60 human cell lines representing 16 tissue origins and 20 cancer types, comprising 240,957 single-nucleus RNA-seq and 223,347 single-nucleus ATAC-seq profiles. Integrative analyses revealed extensive...
Multi-omics analysis reveals chromatin and transcriptomic remodeling in hippocampal CA1 following adolescent social isolation
Social isolation (SI) during adolescence is associated with long-term vulnerability to psychiatric disorders; however, its effect on the hippocampal epigenome and transcriptome remains unclear. Here, we performed integrative ATAC-seq and RNA-seq of the hippocampal CA1 region using an adolescent mouse SI model, combined with single-cell RNA-seq reference mapping and cell type deconvolution. ATAC-seq identified SI-associated alterations in chromatin accessibility, including an increase in...
Epigenetic changes can be inherited without changing DNA in animals
Epigenetic changes can be inherited without changing DNA in animals Gaby Clark Scientific Editor Robert Egan Associate Editor Typically, the information encoded in DNA allows organisms to develop, function, and pass traits across generations. Yet DNA alone does not explain how genes are switched on and off in different cells and environments. This regulation is partly controlled by other factors called epigenetics, such as DNA methylation, a chemical modification that can influence gene...
Scientists discover inherited traits that break Mendel’s Laws of genetics
Scientists discover inherited traits that break Mendel’s Laws of genetics - Date: - June 1, 2026 - Source: - Johns Hopkins Medicine - Summary: - A major mouse study found that some inherited traits are passed down through epigenetic changes that break the classic rules of genetics. Researchers discovered hundreds of cases where these chemical DNA marks behaved unexpectedly, including some that seemed to emerge out of nowhere. They also identified the first known naturally occurring...