European Ancestry
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Equitable Health Intelligence: An Open Benchmark of Multi-Population Machine Learning for Omics-Based Cancer Prognosis
Purpose: Machine learning (ML) models for omics-based cancer prognosis are often trained on data from predominantly European-ancestry populations, producing biased predictions for other populations and undermining equitable genomic medicine. Existing fairness benchmarks mainly focus on outcome parity rather than predictive performance parity across populations. Public benchmark resources are needed for systematically detecting and mitigating such performance disparities in multi-population...
Annotation-Informed Block-Sparse Bayesian Modeling for cis-Expression Prediction
arXiv:2606.00483v1 Announce Type: cross Abstract: Genotype-based cis-expression prediction depends on accurately modeling local regulatory architecture. We present block-sparse Bayesian sparse linear mixed model (bsBSLMM), an extension of Bayesian sparse linear mixed model (BSLMM) that incorporates linkage disequilibrium (LD)-block spike-and-slab sparsity and a transcription start site (TSS)-informed SNP inclusion prior. Across 23,098 genes from GEUVADIS European-ancestry lymphoblastoid cell...
Huge study of Alzheimer’s genetics identifies new drug targets
The biggest genetic study of Alzheimer’s disease so far has identified 127 gene locations that are associated with the condition, of which 48 are new. The study also pinpoints several genes that could be prioritised as drug targets and cell types linked to a higher genetic risk of the condition. “It’s an exciting time for Alzheimer’s genetics,” says Rudolph Tanzi at Massachusetts General Hospital, who provided evidence of the first Alzheimer’s-linked gene, APP, in 1987.
Unpicking endometriosis reveals how it affects more than the pelvis
A huge study into the biology of endometriosis has revealed new mechanisms by which it may cause its severe and wide-ranging effects on health, paving the way for improved treatments. The work, which included data from more than a million women, is also the first to identify specific genes linked to endometriosis in people of African ancestry, a group that has historically been under-represented in research on the condition. “We were able to pinpoint around 300 genes that are going to be...
Perspective on Bias in Biomedical AI: Preventing Downstream Healthcare Disparities
Announce Type: replace Abstract: Healthcare disparities persist across socioeconomic boundaries, often attributed to unequal access to screening, diagnostics, and therapeutics. However, this perspective highlights that critical biases can emerge much earlier, during data collection and research prioritization, long before clinical implementation, particularly in studies focused on molecular and omics data. A vast number of studies focus on collecting omics data, but the demographic...
Scientists discovered something surprising about french fries and diabetes
Scientists discovered something surprising about french fries and diabetes French fries may be driving potatoes’ bad reputation, while other potato dishes seem far less risky for type 2 diabetes. - Date: - June 3, 2026 - Source: - BMJ Group - Summary: - French fries may be the real potato problem.
Rare wild goats in Northumberland prove to be a genetically distinct breed
Rare wild goats in Northumberland prove to be a genetically distinct breed Gaby Clark Scientific Editor Robert Egan Associate Editor New research shows Cheviot goats are one of the UK's most genetically distinct goat populations. Led by Newcastle University, this is the first genetic study to determine the ancestry and genetic health of a UK feral goat population. It provides a genetic assessment of the Cheviot goats in Northumberland's College Valley, identifying them as a historically...
Ancient DNA reveals how women helped transform prehistoric Europe
Ancient DNA reveals how women helped transform prehistoric Europe Ancient DNA reveals a surprisingly dynamic Europe, where marriage, migration, and cultural exchange reshaped populations long before recorded history. - Date: - May 30, 2026 - Source: - The Conversation - Summary: - New DNA evidence shows that Europe’s hunter-gatherers and early farmers interacted far more closely than previously thought, with women likely playing a crucial role in spreading farming across northwestern Europe....
Thirty years at El Mirón cave uncover 40,000 years of Iberian prehistory
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So You Want a Coat of Arms
The first thing you notice upon entering the College of Arms, in London, is a small and incongruously blue statue of a kiwi, clutching a gold axe in its right claw. Sorry, let me try that again: In the odd historic language of heraldry, this is “a kiwi Azure grasping in the dexter foot an ice axe bendwise Or. ”The bird belongs to the coat of arms of Sir Edmund Hillary, a New Zealander, who was part of the first team to conquer Mount Everest.