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A Distribution-Free Framework for Rewrite-Based Human-text Detection via Knockoff Filtering
arXiv:2606.00402v1 Announce Type: cross Abstract: We propose a distribution-free statistical framework that converts arbitrary rewrite-based detectors into detectors with finite-sample FDR guarantees without retraining. Our key observation is that rewrite-based detection implicitly constructs knockoff samples, enabling LLM-generated text detection to be formulated as a multiple hypothesis testing problem with knockoff structure. This perspective separates the design of detection statistics...
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...
Coordinated neural, metabolic and muscular transcriptomic signatures associated with mite-biting behavior in honeybees (Apis mellifera L.)
Biting behavior is an important natural defense mechanism in honeybees (Apis mellifera) against Varroa destructor. Significant variation in this behavior exists across genetic lines of honeybees, with certain colonies exhibiting higher mite-biting activity than others. Selective breeding for enhanced biting behavior provides a promising strategy for sustainable mite control and colony resilience.
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
Fasting Status and Epigenetic Clock Stability: Implications for Aging Research
Background: Epigenetic clocks are DNA methylation-based biomarkers increasingly used in aging research and clinical trials. A recent assessment of 18 clocks across multiple short-term perturbations concluded that most demonstrate only moderate biological reliability, raising concerns about their translational utility. However, understanding biological variability requires understanding the construction of each clock: different clocks capture distinct biological properties that respond...
Genotype and methylation interact to reconfigure transcriptional regulation in colorectal cancer
Background Transcriptional regulation is shaped by both genomic variants and the environment. Yet, how the regulatory effects of genomic variants are reconfigured by dynamic epigenomic changes during tumorigenesis remains incompletely understood. Methods We investigated methylation context-dependent links between genotype and gene expression in colorectal cancer (CRC) using paired tumor and normal-adjacent tissue (NAT) from 80 patients, thereby controlling for germline genomic background.
Obama Writes His Own Story
On a recent morning at Chicago’s new Obama Presidential Center, the institution’s leadership discussed presidential papers the way a decluttering convert might talk about some old sweaters they tossed because they did not spark joy. The campus contains many features sure to delight the misty-eyed visitors who will flock here once it opens, on June 19: a museum that can come across like a pep talk from a more hopeful time; a light-filled basketball court; a whimsical playground; a public...
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.
A spectral audit framework reveals task-dependent aperiodic reliance across EEG and ECG deep learning
arXiv:2606.08583v1 Announce Type: new Abstract: Deep learning on physiological time series is interpreted through domain-specific features -- oscillatory rhythms in EEG, morphological complexes in ECG -- yet these signals sit atop a broadband aperiodic 1/f-like envelope that covaries with arousal, age, and pathology. We introduce a spectral audit framework combining aperiodic/periodic decomposition, phase-preserving Fourier interventions, sham controls, and simulation validation. Aperiodic...