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Segmentation gene expression and function in Vanessa cardui, an emerging model for Lepidoptera
Although all insects are segmented, the genes that control this process vary across species. Many of the pair-rule (PR) genes that direct segment formation in Drosophila are similarly utilized in other holometabolous insects, but more distantly related species use different genes for PR-patterning. Previously, we showed that Lepidoptera lack a highly conserved PR-gene, paired.
Scalable Single-Cell Gene Expression Generation with Latent Diffusion Models
arXiv:2511.02986v2 Announce Type: replace-cross Abstract: Computational modeling of single-cell gene expression is crucial for understanding cellular processes, but generating realistic expression profiles remains a major challenge. This difficulty arises from the count nature of gene expression data and complex latent dependencies among genes. Existing generative models often impose artificial gene orderings or rely on shallow neural network architectures.
Living brain gene activity revealed noninvasively through programmable blood test
Living brain gene activity revealed noninvasively through programmable blood test Stephanie Baum Scientific Editor Robert Egan Associate Editor Cell function is determined by how DNA is expressed into proteins. That process includes two main steps—transcription, when messenger RNA (mRNA) makes copies of active genes; and translation, when mRNA guides protein assembly. Knowing which genes are active at any given moment would make it possible to track the body's response to factors in the...
New 'SMArT' platform makes gene editing in hematopoietic stem cells more efficient and safer
New 'SMArT' platform makes gene editing in hematopoietic stem cells more efficient and safer Sadie Harley Scientific Editor Robert Egan Associate Editor A team of researchers led by Luigi Naldini at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) has developed a new strategy to significantly improve the precision and safety of CRISPR-Cas9 gene editing in human blood stem cells, potentially overcoming one of the major barriers limiting broader clinical application of genome...
The risk of relationship breakdown can be influenced by our genes
The risk of relationship breakdown can be influenced by our genes Lisa Lock Scientific Editor Andrew Zinin Lead Editor Genetics influences who of us are more likely to experience a relationship breakdown, and who are more likely to remain together. But genes are not decisive, new research shows. "Our destiny does not lie in our genes, but if a relationship were a jigsaw puzzle, our genetics would make up some of the pieces that can influence the risk of a breakup," says sociologist Ruth Eva...
Antimicrobial activity of polymyxin A, and characterisation of the cognate biosynthetic gene cluster within the genome of the producing Paenibacillus polymyxa.
We report the isolation and identification of a Paenibacillus polymyxa strain from the citizen science project; Swab and Send. Through whole genome sequencing we are able to describe the biosynthetic gene cluster of polymyxin A produced by P. polymyxa 1G (NCBI accession no. JBVPZV000000000), compare the pmxA, pmxB and pmxE genes to five other polymyxin genes encoding known polymyxin variants, and provide mass spectrometry data that supports the production of polymyxin A1 (1157 m/z) and A2...
Local genetic neighbourhoods but resilient gene flow across anthropogenic landscapes in the red campion (Silene dioica)
In the plant kingdom, gene flow occurs through pollen and seed dispersal, shaping both within-population spatial genetic structure and among-population genetic differentiation. Anthropogenic land-use change can affect levels of gene flow by reducing pollinator abundance and altering pollen and seed dispersal pathways. Yet, how environmental features shape gene flow events in common herbaceous plants - a fundamental building block of many ecosystems - remains poorly understood.
DropSynth-Gold: Golden Gate Assembly in Emulsions Extends Multiplexed Gene Libraries to Greater Lengths
The ability to synthesize longer genes at scale remains a central challenge in multiplexed gene synthesis. DropSynth is a pooled gene synthesis platform that enables highly multiplexed, compartmentalized assembly from microarray-derived oligonucleotides, but current implementations rely on polymerase cycling assembly (PCA), which constrains fragment number, construct length, and assembly fidelity. Here we present DropSynth-Gold, an evolution of the DropSynth platform that replaces PCA with...
The Y chromosome is home to surprising jumping genes
The Y chromosome is home to surprising jumping genes Stephanie Baum Scientific Editor Robert Egan Associate Editor The humble Y chromosome may be the smallest chromosome in the mammalian genome (and getting even smaller), but it is mighty: Genes on the Y chromosome are critical for fertility in males. In a new study in the journal Current Biology, researchers at the University of Michigan Medical School have studied deer mice to outline how the Y chromosome defends itself against decay by...
Are we getting to the point where it's safe to gene-edit babies?
When a rogue researcher in China revealed in 2018 that he had used CRISPR to create three gene-edited children, his actions were almost universally condemned by biologists around the world. The main objection was not that gene-editing babies is wrong in itself, but that the CRISPR technique used was not safe and had a very high risk of causing harmful mutations. Now, a team in the US has used an improved form of CRISPR, known as base editing, to edit healthy embryos and shown that it can be...