Genotoxic
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Related Articles from SNS
DNA Replication under Thermal, Chemical, and Genotoxic Stress
arXiv:2606.08138v1 Announce Type: new Abstract: Eukaryotic DNA replication must remain robust under thermal, chemical, and genotoxic stress despite large fluctuations in replication dynamics. Here, we develop a lattice-based stochastic Monte Carlo framework for whole-genome replication in Saccharomyces cerevisiae at single base-pair resolution, incorporating probabilistic origin firing, replication fork-speed distributions, and a time-dependent limiting factor that governs the availability...
Efficient base editing and development in human embryos without chromosomal alterations
Cas9-based tools enable the introduction of genetic lesions to investigate DNA repair outcomes and edit the genome at disease-relevant loci. DNA double-strand breaks (DSBs) induced by CRISPR/Cas9 result in frequent aneuploidy and large deletions, revealing a repair deficiency in early human embryos and limiting the clinical application of this technology. Here we evaluated the DNA repair outcomes of DNA nicks and mismatches introduced using base editors in human embryos at two targets, PCSK9...
New 'SMArT' platform makes gene editing in hematopoietic stem cells more efficient and safer
New 'SMArT' platform makes gene editing in hematopoietic stem cells more efficient and safer Sadie Harley Scientific Editor Robert Egan Associate Editor A team of researchers led by Luigi Naldini at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) has developed a new strategy to significantly improve the precision and safety of CRISPR-Cas9 gene editing in human blood stem cells, potentially overcoming one of the major barriers limiting broader clinical application of genome...
Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma
Loss of the Y chromosome (LOY) is associated with poor survival across multiple solid tumors, yet the underlying molecular mechanisms remain poorly understood. Here, we identify LOY as a central driver of lineage plasticity and epigenetic heterogeneity in lung adenocarcinoma. Integrating multi-omic profiling of primary samples with isogenic cellular models, we show that LOY triggers epithelial-to-mesenchymal transition (EMT).