Glioblastomas
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Related Articles from SNS
What is glioblastoma and why is it so hard to treat?
Glioblastoma is one of the deadliest cancers — why is it so hard to treat? Mon 8 Jun 2026 at 2:01pm The death of former Australian of the Year Richard Scolyer overnight came after a multi-year fight with one of the most difficult to treat cancers. Glioblastoma is known as the most aggressive form of brain cancer.
Nanofiber implant delivers three drugs, doubles survival in glioblastoma mice
Nanofiber implant delivers three drugs, doubles survival in glioblastoma mice Lisa Lock Scientific Editor Andrew Zinin Lead Editor Researchers with the University of Cincinnati and Johns Hopkins Medicine developed a potential treatment for brain cancer that uses nanofibers embedded with a combination of drugs that work in concert to target tumors. The drugs proved more effective in combination than when administered alone and can provide both immediate and long-lasting doses to kill cancer...
Radiosensitization of Glioblastoma by the K-ras Inhibitor RMC-6236
Purpose: Glioblastoma (GBM) is characterized by poor clinical outcomes and marked resistance to radiotherapy. Because effective radiosensitizing strategies for GBM remain limited, we investigated whether inhibition of KRAS/RAS signaling could enhance radiation response in GBM. In particular, we evaluated the radiosensitizing potential of RMC-6236, an RAS(ON) multiselective inhibitor that suppresses active RAS signaling across multiple RAS-dependent states.
Do Foundation Models See Biology? Evaluating Attention Coherence with Spatial Transcriptomics in Glioblastoma
Announce Type: new Abstract: Whether attention maps from pathology foundation models capture genuine biology remains unknown, yet this question is critical for clinical trust and regulatory approval. We propose a spatial transcriptomics-based framework for orthogonal, hypothesis-free evaluation of attention and apply it to five pathology foundation models (CONCH v1.5, UNI v2, Virchow2, GigaPath, H-Optimus-1) and a ResNet50 baseline. Using attention-based multiple instance learning, we train...
Richard Scolyer Has Died
Australian doctor who underwent world-first brain tumour treatment dies Pioneering Australian doctor Richard Scolyer has died, three years after being diagnosed with an aggressive brain tumour. Scolyer, 59, made global headlines for his decision to undergo a risky world-first experimental treatment for his glioblastoma at the hands of his friend Professor Georgina Long - based on the pair's own scientific breakthroughs in skin cancer. Their work on advanced melanoma - once a death sentence -...
Intra-slide calibration technology improves immunohistochemical harmonization within and between anatomic pathology laboratories
The reproducibility of immunohistochemistry in tumor tissue analysis across reference labs remains a persistent challenge. We tested the extent to which an intra-slide calibration technology mitigated discprepencies in inter-laboratory assays of p53 immunohistochemical (IHC) reactions in brain biopsies of glioblastoma (GB), IDH-wildtype. Intra-slide calibration technologies apply a 0-100% concentration scale incorporating primary surrogate and secondary antibodies to generate a standardized...
Scientists supercharge natural killer cells to fight aggressive cancers
Scientists at McGill University have found a way to supercharge the immune system’s natural killer (NK) cells, helping them break through the defenses tumors use to stay alive. By temporarily blocking two proteins, researchers turned these cells into far more effective cancer fighters against difficult cancers like leukemia, glioblastoma, kidney cancer, and triple-negative breast cancer.
Iron-deficiency in the tumor microenvironment reprograms tumor-immune interactions in a sex biased manner
Background: Glioblastoma (GBM) is a sex-biased disease characterized by higher incidence and poorer survival in males. These sex differences are primarily driven by metabolic and immune signatures, with iron metabolism playing a major role. While iron is essential for tumor cell proliferation, it is also critical for T cell recruitment and function within the tumor microenvironment (TME).
FBI manhunt for woman accused of faking terminal brain cancer to scam family and friends out of thousands
FBI manhunt for woman accused of faking terminal brain cancer to scam family and friends out of thousands The allegations against the Pennsylvania woman are ‘nauseating,’ a U.S. attorney said. - Bookmark The FBI is hunting for a woman accused of faking terminal brain cancer and scamming her loved ones out of thousands of dollars. Vanessa O’Rourke, a 37-year-old originally from Harleysville, Pennsylvania, lied about having glioblastoma, a terminal brain cancer, and told her friends and family...
Warren Buffett disciple Guy Spier built career on value investing. A rare cancer changed everything
Noted value investor Guy Spier first gained the public's attention in 2007 when he and a partner paid more than $650,000 at a charity auction to have lunch with the world's most famous value investor, Warren Buffett. Spier, who calls Buffett his hero, launched his Zurich-based fund Aquamarine in 1997. He mimicked the Oracle of Omaha's investing philosophy, anchored on the premise of compounding interest.