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The First Nozzle-Mounted Compton Camera Prompt Gamma Imaging System for In Vivo Proton Therapy Dose Verification
arXiv:2606.03978v1 Announce Type: new Abstract: This study presents the first clinical integration and experimental demonstration of a nozzle-mounted Compton camera prompt gamma imaging (PGI) system for in vivo proton range verification. Four position-sensitive solid-state Compton camera modules, each containing four cadmium zinc telluride (CdZnTe) detector crystals, were integrated into a modified range shifter mounted directly on the treatment nozzle of a clinical proton therapy gantry....
Radiation damage to normal mammalian tissue in vivo with laser-driven protons at ultra-high instantaneous dose rate
Announce Type: replace Abstract: The differential sparing of normal tissues relative to tumor control observed at ultra-high dose rates, referred to as the FLASH effect, has recently gained considerable attention. The therapeutic advantages of FLASH radiotherapy are expected to be further amplified through the use of protons and ions, which enable precise dose deposition at tumor depth while minimizing irradiation of healthy tissues proximal and distal to the target. Nevertheless, the...
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.
Decoding Chromosome Radiosensitivity in G0-Phase PBMCs: Genomic Determinants, Age, Sex effects, and Implications in Radiation Dose Assessment
Low-dose ionizing radiation from natural and anthropogenic sources is typically not of significant concern under normal conditions. However, in case of radiological incidents, it becomes an important environmental hazard, raising concern for public health and necessitating reliable biological indicators of exposure. Chromosomal aberrations are most reliable markers of radiation exposure and are more or less universally assessed in metaphases.
Proton FLASH preserves neurocognition across delivery techniques: implications for clinical translation in pediatric brain tumors
Background: Radiation therapy is integral to the curative treatment of childhood brain tumors but contributes to late neurocognitive impairment in survivors. FLASH (ultra-high dose rate, >40Gy/s) reduces normal-tissue toxicity in preclinical models, and proton-FLASH is currently the only modality capable of delivering ultra-high dose rates to the deep targets, such as pediatric brain tumors. However, two questions remain unresolved before clinical translation: (1) whether the FLASH effect...