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Variable zinc concentrations among commercially available Mueller-Hinton Broth brands affects SIR interpretations during broth microdilution in vitro antimicrobial susceptibility testing with the novel metallo-beta-lactamase inhibitor APC148

The well-known discrepancy between the in vitro and in vivo efficacy of {beta}-lactam antibiotics in metallo-{beta}-lactamase (MBL) containing Gram-negative bacteria has during recent years been found to be at least partially explained by zinc levels at infection sites being much lower than those found in conventional cation-adjusted Mueller-Hinton Broth (caMHB) media used for in vitro susceptibility testing. Previous studies have also demonstrated that a high variability exists with respect...

bioRxiv 5d ago

Synthetic Benchmarks Overstate Forward-Forward Scaling: Real-Data Limits of Layer-Local Training

new Abstract: Forward-Forward (FF) learning [Hinton, 2022] replaces backpropagation with strictly layer-local goodness updates. Recent FF-CNN work has narrowed the gap to BP on 32x32 benchmarks, raising the question of whether layer-local training is becoming a viable alternative at realistic scale. To probe this rigorously, we develop DTG-FF -- dynamic temperature goodness, decoupled normalization, and multi-layer fusion -- as an instrument that sets FF-family state of the art across nine...

arXiv CS 2d ago

Human-Like Neural Nets by Catapulting

Human-like Neural Nets by Catapulting Speculative proposal to create artificial neural nets with human-like performance by high-learning-rate/regularization training of overparameterized NNs to trigger catapulting/grokking. Over-parameterization as a route to true generalization would resolve many outstanding mysteries of artificial versus natural intelligence. There are many mysteries about deep learning and human intelligence, but we could describe the biggest anomaly this way: why are...

Hacker News 3d ago

Near-axis quasi-isodynamic database

arXiv:2601.08400v3 Announce Type: replace Abstract: In this work, we investigate the landscape of quasi-isodynamic stellarators using the near-axis expansion of the magnetic field. Building on recent theoretical developments, we construct a database of more than 800,000 stable, approximately quasi-isodynamic vacuum magnetic configurations. These configurations span a range of field period numbers and other geometric control parameters, including the magnetic axis shape and plasma elongation.

arXiv Physics 9d ago

Efficient and accurate neural-field reconstruction using resistive memory

Abstract Applications such as medical imaging, augmented and virtual reality, and embodied artificial intelligence (AI) depend on the ability to reconstruct complex signals from sparse observations. These applications are characterized by incomplete measurements and limited computational resources. Traditional approaches to digital hardware face the following challenges: explicit signal representations require heavy sampling and storage, data movement across the von Neumann bottleneck...

Nature 22h ago