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Hybrid Probabilistic Forecasting of Under-Five Malaria Admissions in Ghana: A Gaussian Process Regression with Holt-Winters Smoothing
Announce Type: cross Abstract: Accurate malaria forecasting remains a major challenge in sub-Saharan Africa, where strong seasonality, reporting uncertainty, and non-stationary transmission dynamics reduce the reliability of conventional models. In Ghana, district-level malaria surveillance requires forecasting frameworks that are probabilistically rigorous and robust under limited data. This study proposes a hybrid framework integrating Gaussian Process Regression (GPR) with Holt-Winters...
South Carolina assisted living manager fired after mocking Pam Bondi's cancer diagnosis in viral video
A South Carolina assisted living facility manager has been fired following online backlash after posting a video mocking Pam Bondi's thyroid cancer diagnosis, prompting criticism across social media. A TikTok video reposted Saturday by the X account, "I Meme, Therefore I Am," showed Rosalyn Holt, a former business office manager at Helena Square Assisted Living in Port Royal, South Carolina, apparently recording a video at work while mocking Bondi's diagnosis. In one image featured in the...
Super Typhoon Sinlaku triggered atmospheric gravity waves visible from space
Super Typhoon Sinlaku triggered atmospheric gravity waves visible from space A record-early super typhoon sent giant atmospheric ripples into near-space, offering scientists a new clue for tracking powerful storms. - Date: - June 3, 2026 - Source: - NASA Earth Observatory - Summary: - One of the most powerful typhoons ever recorded this early in the Pacific season did more than unleash flooding and extreme winds—it sent enormous ripples all the way into the upper atmosphere.
Men's Way-Too-Early Top 25: Kansas, UNC in after d...
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Tony Awards 2026 Highlights: See Biggest Wins and Performances
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A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
Gleam v1.17.0 Released
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Doctors thought this kidney drug helped some patients. It may help millions more.
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Pickup truck carrying trailer full of fireworks explodes on Tennessee highway
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