ICI

Icy moons' ability to host life could be revealed through an ecology-based method

Icy moons' ability to host life could be revealed through an ecology-based method Sadie Harley Scientific Editor Robert Egan Associate Editor New observatories and spacecraft missions are probing environments in our solar system that could potentially host life but have long remained hidden. Icy moons like Saturn's Enceladus and Jupiter's Europa likely contain oceans beneath frozen outer shells. But a layer of ice prohibits space probes from sampling them directly.

‘Significant’ storm to hammer millions in WA and bring icy weather to NSW, Victoria and SA

Bureau of Meteorology says WA residents should brace for wind gusts higher than 125km/h – the strength of category two cyclonesGet our breaking news email, free app or daily news podcastA major storm system bearing down on millions of Western Australians on Saturday is bringing cyclone-strength winds, and is set to deliver a “wintry blast” to the east of the country early next week.Residents across WA’s populated south-west were warned to tie down loose items and prepare for destructive wind...

Autoantibodies Drive Fc Gamma Receptor-Dependent Colon Inflammation During Immune Checkpoint Blockade

Immune-related adverse events (irAEs), particularly colitis, are major limitations of immune checkpoint inhibitor (ICI) therapy, but their mechanisms remain poorly understood. Here we show that endogenous autoantibodies (AAbs) can promote ICI-associated colitis through Fc gamma receptor (FcgR) dependent pathways. IgG from melanoma patients treated with pembrolizumab, nivolumab, or ipilimumab, with or without severe colitis, was transferred into wild-type or humanized FcgR (hFcgR) mice...

How waves, ponds and green algae are accelerating sea ice melt in Antarctica

How waves, ponds and green algae are accelerating sea ice melt in Antarctica Lisa Lock Scientific Editor Andrew Zinin Lead Editor Picture sea ice in your mind. You probably imagine brilliant white, snow-covered floes floating on the surface of the ocean, home to penguins in the south of the globe or polar bears in the north. But our new research shows Antarctic sea ice can turn into rafts of rotting floes (the free-floating pieces of ice) or an icy green slush when it interacts with waves in...

Playground no more: Thais sick of badly behaved tourists hail stricter visas

Government cites crime and drunken antics of foreigners as it shortens their stays – with ordinary Thais welcoming the crackdownIt’s late afternoon at Bangkok’s Khaosan road, the city’s backpacker strip. Bar staff are calling after passersby, enticing them inside with drinks promotions. The smell of cannabis, widely sold in the city, wafts into the street, where vendors sell anything from fake tattoos, flip-flops and icy fruit shakes.

Playground no more: Thais sick of badly behaved tourists hail stricter visas

Government cites crime and drunken antics of foreigners as it shortens their stays – with ordinary Thais welcoming the crackdownIt’s late afternoon at Bangkok’s Khaosan road, the city’s backpacker strip. Bar staff are calling after passersby, enticing them inside with drinks promotions. The smell of cannabis, widely sold in the city, wafts into the street, where vendors sell anything from fake tattoos, flip-flops and icy fruit shakes.

Ötzi's frozen remains may harbour metabolically active microbes

Some of the microbes lingering on the 5300-year-old remains of “Ötzi the Iceman” may still be metabolically active, despite being kept in icy conservation conditions. Ötzi’s mummified body was discovered in 1991 thawing out of an Alpine glacier close to the border of Austria and Italy. He is estimated to have lived at some point between 3350 and 3120 BC, and in the 35 years since he was found, studies of his remains have revealed a treasure trove of information, including that he was...

Expedition to Antarctica advances research on potential melanoma treatment

Expedition to Antarctica advances research on potential melanoma treatment Lisa Lock Scientific Editor Andrew Zinin Lead Editor Deep beneath the icy waters surrounding Antarctica, a small marine organism may hold clues to a future cancer treatment. Researchers from USF recently returned from a six-week expedition in one of the most remote environments on Earth to study a species of ascidian, or sea squirt, that contains a bacterium capable of killing melanoma cancer cells. The discovery was...

La Turquie et l’Australie défendront un objectif d’électrification lors de la prochaine COP

Repetition Selectively Reconfigures Offset-Defined Temporal Integration in Auditory Cortex

Auditory perception requires integrating sound over time, but whether cortical integration windows are fixed or adaptively shaped by recent sensory history remains unclear. Because auditory offset responses are shaped by the temporal structure preceding sound termination, they provide a readout of offset-defined temporal integration. Here, we recorded single-unit activity in awake rat auditory cortex while presenting 512-ms click trains with inter-click intervals of 1, 2, 4, 8 or 16 ms.