IHC
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Related Articles from SNS
Deep Learning for Generating Computational PIN-4 Immunohistochemistry Staining from Prostate Biopsy H&E Images
arXiv:2606.01871v1 Announce Type: new Abstract: Immunohistochemistry (IHC)is frequently used to resolve diagnostically ambiguous prostate cancer biopsy findings on hematoxylin and eosin (H&E)-stained tissue. However, PIN-4 IHC staining is typically performed on adjacent tissue sections, limiting direct spatial comparison between the H&E morphology and the corresponding immunophenotypic signal.
Prandtl number dependence of rotating internally heated convection
Announce Type: replace Abstract: We investigate the influence of the Prandtl number ($Pr$) on penetrative internally heated convection (IHC) in both non-rotating and rotating regimes using three-dimensional direct numerical simulations. By varying $Pr$ between 0.1 and 100, we show that the global mean temperature $\langle \overline{T} \rangle$ is not very sensitive to $Pr$, and is primarily controlled by the dynamics of the unstably stratified top boundary layer. In contrast, the Prandtl...
Intra-slide calibration technology improves immunohistochemical harmonization within and between anatomic pathology laboratories
The reproducibility of immunohistochemistry in tumor tissue analysis across reference labs remains a persistent challenge. We tested the extent to which an intra-slide calibration technology mitigated discprepencies in inter-laboratory assays of p53 immunohistochemical (IHC) reactions in brain biopsies of glioblastoma (GB), IDH-wildtype. Intra-slide calibration technologies apply a 0-100% concentration scale incorporating primary surrogate and secondary antibodies to generate a standardized...
MTAP deficiency is a novel biomarker in neuroendocrine neoplasms of the lung
Abstract Introduction: MTAP emerges as potential predictive biomarker for MTA-cooperative PRMT5 inhibitors. Although MTAP attracts increasing attention in non-small cell lung cancer, its role in pulmonary neuroendocrine neoplasms (NENs) remains largely unexplored. Methods: Here, we assessed the prevalence of MTAP deficiency in 209 pulmonary NENs using immunohistochemistry (IHC).
A Pathology Foundation Model for Gastric Cancer with Real-World Validation
arXiv:2606.04792v1 Announce Type: new Abstract: Gastric cancer remains a major cause of cancer mortality, yet its histological and molecular heterogeneity complicates diagnosis and risk stratification. General-purpose pathology foundation models (PFMs) often plateau on fine-grained endpoints central to gastric cancer care, and few have undergone rigorous prospective validation or clinical reader studies. We present GRACE, a Gastric-specific foundation model for Real-world Assessment and...
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.