Joint Nonnegative Matrix Factorisation (Joint NMF
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Multivariate integration of histological images and gene expression data: a comparative review
Integrating histological images with gene expression data offers a promising approach for linking tissue morphologies to molecular signatures and improving disease subtyping. However, such integration remains challenging due to the high dimensionality of these datasets, cross-modal heterogeneity, and limited interpretability. Multivariate methods such as Sparse Canonical Correlation Analysis (Sparse CCA), Joint Nonnegative Matrix Factorisation (Joint NMF), and Angle-based Joint and...