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A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Chaos as Tesla ploughs into Wigan house and 999 crews flood street as two injured
Chaos as Tesla ploughs into Wigan house and 999 crews flood street as two injured Emergency services rushed to the scene on Bag Lane, Atherton, Wigan, after a Tesla was involved in a collision with a house, with two people taken to hospital A house has been left in ruins after a Tesla car smashed into it. Emergency services were called to Bag Lane, in Atherton, in the Wigan borough, at 11.23pm on Thursday night (June 4). Two fire engines rushed to the scene, near the junction with Mealhouse...
Heathrow traffic live: Man, 63, dead and woman critical after horror M4 crash
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M25 traffic live: Huge fuel spill sparks 7 miles of queues and 90 minute delays
Huge fuel spill sparks 7 miles of queues and 90 minute delays Drivers are facing delays of up to 90 minutes this morning after fuel spilled from a truck across a section of the M25 between J27 and J26 anti-clockwise causing seven miles of queues Commuters on the M25 face traffic chaos this morning as three of four lanes are closed after a truck spilled fuel across the carriageway. Specialists are on the scene with emergency road resurfacing taking place between J27 and J26 anti-clockwise...
M25 traffic live: Huge fuel spill sparks 7 miles of queues and 90 minute delays
Huge fuel spill sparks 7 miles of queues and 90 minute delays Drivers are facing delays of up to 90 minutes this morning after fuel spilled from a truck across a section of the M25 between J27 and J26 anti-clockwise causing seven miles of queues Commuters on the M25 face traffic chaos this morning as three of four lanes are closed after a truck spilled fuel across the carriageway. Specialists are on the scene with emergency road resurfacing taking place between J27 and J26 anti-clockwise...
Nir1-Nir2 Heterodimerization Confers Robustness to the Phosphoinositide Cycle
The phosphatidylinositol (PI) cycle maintains plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate (PIP2) levels to sustain signaling and cellular homeostasis in receptor-stimulated cells. This process requires recruitment of the PI transfer protein Nir2 to endoplasmic reticulum (ER)-PM junctions where PI and phosphatidic acid are exchanged between the two membranes. Nir2 recruitment is promoted by its paralog Nir1, which lacks PI transfer activity but is constitutively localized to...
London tube strikes live: Multiple Tfl lines hit as Piccadilly and Waterloo & City suspended
London tube strikes live: Multiple Tfl lines hit as Piccadilly and Waterloo & City suspended There is more tube strikes travel misery for commuters in London this morning with multiple underground lines either suspended or busier than usual London has been hit by the second major Tube strike in a week this morning, bringing travel misery across the capital with no service at all on two underground lines and parts of three others. Crowds of people have been left stranded on platforms while...
Tube strikes 2026 live: London chaos with multiple Tfl lines hit - full list
Tube strikes 2026 live: London chaos with multiple Tfl lines hit - full list There is more travel misery for commuters in London this morning with underground lines either suspended or busier than usual London has been hit by the second major Tube strike in a week this morning, bringing travel misery across the capital and no service at all on two lines and parts of four others. The walkout follows an earlier strike on Tuesday which left crowds of people stranded on platforms while others...
M25 traffic live: Motorway fire causes traffic chaos as 999 crews rush to scene
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Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.