K-Ras
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Related Articles from SNS
Radiosensitization of Glioblastoma by the K-ras Inhibitor RMC-6236
Purpose: Glioblastoma (GBM) is characterized by poor clinical outcomes and marked resistance to radiotherapy. Because effective radiosensitizing strategies for GBM remain limited, we investigated whether inhibition of KRAS/RAS signaling could enhance radiation response in GBM. In particular, we evaluated the radiosensitizing potential of RMC-6236, an RAS(ON) multiselective inhibitor that suppresses active RAS signaling across multiple RAS-dependent states.
'Transformative' pancreatic cancer drug doubles survival time
A daily pill doubles the survival time of people with pancreatic cancer, one of the most aggressive and difficult-to-treat forms of the condition, even after they have stopped responding to chemotherapy. What’s more, the convenient pill has fewer side effects than standard chemotherapy. “It’s a transformative treatment,” says Pilar Acedo at University College London, who wasn’t involved in the research.