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Macrocyclic Peptide Tools for Huntingtin-bound HAP40
Huntington's disease is a fatal neurodegenerative disorder caused by expansion of a cytosine-adenosine-guanine repeat in exon 1 of the Huntingtin (HTT) gene, resulting in a polyglutamine-expanded HTT protein. Although the genetic cause of Huntington's is well defined, the molecular functions of HTT and the mechanisms linking polyglutamine expansion to neurodegeneration remain incompletely understood. Huntingtin Associated Protein 40 kDa (HAP40) is a key HTT interaction partner that forms a...
Malaysia pushes Norway to expedite US$252 million refund, says Oslo cannot ‘wash its hands of’ missile deal
Malaysia pushes Norway to expedite US$252 million refund, says Oslo cannot ‘wash its hands of’ missile deal Malaysia’s defence minister said Norway cannot absolve itself of responsibility and should help facilitate the refund process, arguing that Oslo’s decision to revoke export licenses triggered the dispute. KUALA LUMPUR: Malaysia has urged Norway to help expedite a refund of more than RM1 billion (US$251.5 million) for a scrapped missile procurement deal, insisting that Oslo cannot...
Light-induced quantum friction of carbon nanotubes in water
Abstract Friction slows down moving objects at both macroscopic and microscopic scales1. At the electronic level, quantum friction describes direct transfer of momentum between a liquid and the electrons of a solid2. Owing to its microscopic nature, this phenomenon remains experimentally challenging to capture3.
Deep Proteoform Sequencing with Top-Down Direct Mass Technology
Individual Ion Mass Spectrometry (I2MS) using Direct Mass Technology mode on an Orbitrap mass spectrometer (DMTm) increases sensitivity, resolution, and mass range for protein analysis. Here, we present an end-to-end workflow for deep proteoform sequencing using top-down mass spectrometry with DMTm. By assigning the charge of individual fragment ions and converting spectra from the m/z to the mass domain, DMTm resolves overlapping isotopic distributions that have limited conventional...
Wangchuk says key points omitted from Ladakh talks draft, warns of hunger strike
Fresh differences surfaced Monday over negotiations on Ladakh’s political future after Leh Apex Body (LAB) accused Centre of omitting key provisions from a draft record of May 22 talks and warned of a renewed agitation, including hunger strikes. LAB member and environmentalist Sonam Wangchuk said representatives had agreed during talks with Union home ministry’s sub-committee that Ladakh would get a democratic structure with an assembly-like body enjoying legislative, executive and financial...
Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).