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Klebsiella

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Antimicrobial peptide naturally found in cows breaks Klebsiella biofilms and kills drug-resistant bacteria

Antimicrobial peptide naturally found in cows breaks Klebsiella biofilms and kills drug-resistant bacteria Stephanie Baum Scientific Editor Robert Egan Associate Editor UCF College of Medicine Assistant Professor Renee Fleeman continues to refine a powerful therapy for drug-resistant bacteria that pierces the gooey coating that anchors and protects such germs from the drugs we take to kill them. Her research has found that an antimicrobial peptide naturally found in cows weakens the biofilm...

Phys.org 7d ago

How anti-CRISPR proteins promote the spread of hospital-acquired infections

Researchers from Skoltech—a VEB.RF group institution—and their colleagues from the U.S. and China have explained how the antibiotic resistance gene established itself in the genome of the bacterium Klebsiella pneumoniae. The findings could help control this widespread microbe, which can cause pneumonia, meningitis and other, often hospital-acquired, infections in patients with weakened immunity. The findings were reported in the Proceedings of the National Academy of Sciences.

Phys.org 3h ago

MRSA, MSSA, Gram-negative bacteraemia and CDI: monthly data, 2025 to 2026

MRSA, MSSA, Gram-negative bacteraemia and CDI: monthly data, 2025 to 2026 MRSA, MSSA, Gram-negative bacteraemia infections by organisation and location of onset, and Clostridioides difficile infections (CDI) by organisation and prior trust exposure. Documents Details For data before January 2025 to 2026, see our previous reports. These official statistics were independently reviewed by the Office for Statistics Regulation in May 2022.

GOV.UK Statistics 7d ago

Variable zinc concentrations among commercially available Mueller-Hinton Broth brands affects SIR interpretations during broth microdilution in vitro antimicrobial susceptibility testing with the novel metallo-beta-lactamase inhibitor APC148

The well-known discrepancy between the in vitro and in vivo efficacy of {beta}-lactam antibiotics in metallo-{beta}-lactamase (MBL) containing Gram-negative bacteria has during recent years been found to be at least partially explained by zinc levels at infection sites being much lower than those found in conventional cation-adjusted Mueller-Hinton Broth (caMHB) media used for in vitro susceptibility testing. Previous studies have also demonstrated that a high variability exists with respect...

bioRxiv 5d ago

A digital droplet microarray for measuring tolerance to antibiotics

Antibiotic tolerance enables populations of microbes to survive normally lethal antibiotic concentrations, increasing the likelihood of reinfection and facilitating the evolution of resistance. Tolerance measurements typically involve quantifying viable cells after antibiotic exposure. Existing methods range from accessible but low-throughput approaches, such as plate counting, to higher-throughput but semi-quantitative techniques, such as the TDtest.

bioRxiv 5d ago