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An Integrating Sphere Based Method for Quantifying RNA Encapsulation Efficiency in Lipid Nanoparticles without Lysis
Encapsulation efficiency (EE) is a critical quality attribute of lipid nanoparticle (LNP)-RNA formulations, determining the fraction of active RNA payload available for delivery and influencing therapeutic potency, dose accuracy, and product consistency. Conventional fluorescence-based EE assays, such as RiboGreen (RG), require detergent-mediated LNP lysis, which can introduce systematic bias arising from incomplete particle disruption and additional sample handling steps. Here, we report a...
One Nation resurgence feels like 'recurring nightmare' for former Qld premier
One Nation cost former Queensland premier Rob Borbidge office. This is his warning for the current government Fri 5 Jun 2026 at 5:33am Former Nationals premier of Queensland Rob Borbidge says alarm bells are ringing within conservative ranks over surging support for One Nation, driven by what he says are "angry" and "fed up" voters. But with the next federal and Queensland elections not due until 2028, Mr Borbidge says there is still time to prevent what some opinion polls suggest could be...
Politically connected company won $15m government contract despite 'red flags'
Former Queensland ALP government awarded $15m contract to politically connected company despite 'red flags' Tue 9 Jun 2026 at 6:24am In short: The former Queensland government awarded an ultimately doomed $15 million contract to cybersecurity company Cryptoloc Holdings despite red flags, auditors have found. An audit of the tender process, obtained by the ABC under Right to Information laws, highlights a series of errors, including multiple issues with the financial accounts. Recommendations...
Katter attempt to dodge ban and debate abortion access shot down by Qld government
Katter attempts to force discussion on abortion access in Queensland parliament despite ban on debate Tue 2 Jun 2026 at 6:48pm In short: An attempt by state MP Robbie Katter to dodge a parliamentary ban on abortion debate has been defeated by 85 votes to 2, with the two votes coming from two KAP MPs. Mr Katter claimed changes to the Medicines and Poisons (Medicines) Amendment Regulation 2026 changed access to abortion medication. Premier David Crisafulli implemented a ban on debate on the...
Active Nuclear Shuttling Enables Efficient Virus-Free CAR Gene Integration Using Ready-to-Use Lipid Nanoparticles
Non-viral engineering of chimeric antigen receptor T (CAR -T) cells is highly desirable to overcome the cost, safety, and scalability limitations associated with viral vectors and electroporation. However, efficient nuclear delivery and stable genomic integration of DNA in primary human T cells remain major challenges. Here, we established a virus-free CAR-T manufacturing platform using lipid nanoparticles (LNPs) combined with a nuclear localization signal (NLS) shuttle strategy.
A differentiable machine learning small-angle X-ray scattering analysis framework for structure elucidation of lipid nanoparticles
Announce Type: new Abstract: Lipid nanoparticles (LNPs) are efficient delivery systems for negatively charged nucleic acids. Their multi-component architecture yields a core-shell structure. Small-angle X-ray scattering (SAXS) is an important characterization technique for LNPs, but recovering internal structure and size distribution from SAXS is an inverse problem with non-unique solutions.
Collecting Duct-Targeted Lipid Nanoparticles Deliver Pkd2 mRNA to Restore Polycystin-2 and Attenuate ADPKD
Autosomal dominant polycystic kidney disease (ADPKD), a leading genetic cause of kidney failure, is caused by mutations in the PKD1 or PKD2 genes, resulting in functional polycystin 1 (PC1) or polycystin 2 (PC2) deficiency, and is characterized by progressive cyst expansion in the kidneys. However, no approved therapy directly restores polycystin expression, and current treatments target downstream pathways rather than the genetic defect. Gene replacement therapy offers a direct route to...
New 50 cent airport bus could cost disheartened Townsville business
New 50 cent airport bus could cost disheartened Townsville business Wed 10 Jun 2026 at 5:31am In short: The Queensland government will launch a 50 cent public bus between the Townsville Airport and CBD locations this month. A shuttle service that has filled the transport gap for a decade is unsure about how the change will affect it. Kinetic's route 222 service will launch on June 26, servicing the airport, bus hub, The Strand, Breakwater ferry terminal and Palmer Street.
A differentiable machine learning small-angle X-ray scattering analysis framework for structure elucidation of lipid nanoparticles
Announce Type: cross Abstract: Lipid nanoparticles (LNPs) are efficient delivery systems for negatively charged nucleic acids. Their multi-component architecture yields a core-shell structure. Small-angle X-ray scattering (SAXS) is an important characterization technique for LNPs, but recovering internal structure and size distribution from SAXS is an inverse problem with non-unique solutions.