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GCK-4 regulates apical actin organization and lumen formation in the C. elegans intestine
Epithelial tubes are an essential component of many organ systems. The formation of their lumens depends on the close coordination of epithelial polarity, the apical actin cytoskeleton, and apical junctions, yet the mechanisms that organize the apical cytoskeleton and junctions downstream of polarity remain poorly understood. Here, we identify the Ste20 family kinase GCK-4, the single C. elegans ortholog of the mammalian kinases LOK and SLK, as a critical regulator of intestinal lumen formation.
Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).
Seattle: A travel guide to the 2026 World Cup host city
Known as the Emerald City, Seattle will host World Cup games for the first time - including the USA's second group D fixture. Few cities in North America can lay claim to better summer weather than Seattle, neatly nestled in the Pacific Northwest with sunny skies and little humidity after Memorial Day. But the Emerald City, which will host the World Cup for the first time in its history, is a destination city for more reasons beyond its temperate climate.
Embryonic tissues can behave like fluids or solids to reshape cell fate signals
Embryonic tissues can behave like fluids or solids to reshape cell fate signals Sadie Harley Scientific Editor Robert Egan Associate Editor Embryonic development is one of the most dynamic biological processes in nature. Cells and tissues organize and reorganize themselves following incredibly precise patterns, while remaining flexible and robust. Scientists are increasingly probing the role the physical properties of embryonic tissues—such as rigidity or stiffness—play in this process.
Osteopontin Mediates Uterine Artery Dysfunction in Hypertensive Pregnancy
Background: Successful pregnancy requires substantial maternal cardiovascular adaptation, including expansion and remodelling of the uterine arteries to support increased nutrient flow to the fetus. Hypertension is associated with impaired uterine artery remodelling and increased risk of fetal growth restriction and other adverse outcomes, yet the mechanisms driving vascular dysfunction in hypertensive pregnancy remain incompletely understood. Osteopontin, a matricellular protein, is...
Govee’s all-weather smart lamp post is under $200 for the first time
A look at how Jennifer’s yard gets a brightness boost thanks to Govee’s smart outdoor lamp post. | Photo: Jennifer Pattison Tuohy / The Verge If you have an outdoor space that needs some extra lighting, either for fun or security reasons (or a mix of the two), the Govee outdoor lamp post light is a good pick that’s 23 percent off its regular price right now.
Stock up now: Emergency essentials are up to 45% off ahead of Prime Day
Ahead of Amazon Prime Day, significant discounts are already available on emergency essentials for your home and car. Whether you need a new smoke detector or a Jackery power station for potential summer blackouts, Amazon has it all. Even FOX-reader favorites, like this portable tire inflator, are nearly half off.
FIFA World Cup 2026: Full schedule, fixtures, groups, India timings, venues, knockout dates
The FIFA World Cup 2026 is set to usher in a new era for international football, with the tournament expanding to 48 teams for the first time in its history. Co-hosted by the United States, Canada and Mexico, the month-long spectacle will run from June 11 to July 19, 2026 (June 12 to July 20 in India), bringing together 48 nations, 1,248 players and a record 104 matches across 16 host cities. The expanded format means more teams, more matches, more knockout football and a longer route to the...
Team USA’s loudest supporters say FIFA pushed them to upper deck for World Cup
When the U.S. men’s national soccer team plays at home, its most loyal fans traditionally sit right behind a goal to cheer on the team or intimidate the opposition. But when the Americans kick off a once-in-a-generation World Cup in Southern California next week, many of those die-hard supporters may be harder to hear because FIFA seated them in the “nose bleeds,” according to a major U.S. fan group. “These are the worst tickets that I’ve ever seen out of the five World Cups I’ve been to,”...
The Best Headlights in the World Are Illegal in America
Driving after dark used to be a haven. Late at night, there’s no rush-hour traffic, just the meditative hum of the passing miles. But these days, my eyes can’t take it anymore.