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Distinct Auditory Thalamocortical Pathologies Underlie Emerging Neurophysiological Dysfunction in a Cln3 Mouse Model of Batten Disease
CLN3 disease, the most common form of the Neuronal Ceroid Lipofuscinoses (NCLs), causes progressive cognitive decline and language impairment in humans. A pathological hallmark is the accumulation of storage material within neuronal lysosomes resulting from mutations in the CLN3 gene. We previously identified parallel deficits in auditory duration mismatch negativity (MMN), an electroencephalography (EEG)-based marker of auditory change detection, in individuals with CLN3 disease and in...
ERP-XTTN: Interpretable Prototype-Guided Cross-Attention for Cross-Subject ERP Classification
arXiv:2606.02939v1 Announce Type: new Abstract: Interpretable brain-computer interface classifiers that generalize across subjects without calibration remain an open challenge. We test whether prototype-based cross-attention can provide competitive, interpretable event-related potential (ERP) classification under deployment-compatible conditions. We propose ERP-XTTN, a cross-attention architecture that routes input EEG patches to fixed difference-wave prototypes via query-key-only...