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Structure-Informed Multiple Sequence Alignment: A Formal Model and Hardness Results

Announce Type: new Abstract: We formulate a structure-informed multiple sequence alignment problem, denoted MSA-S. The model abstracts biological sequences as strings and structural information as designated position-pairs. It augments a fixed pairwise string score, defined by a fixed non-gap symbol-pair scoring rule and fixed affine gap penalties, with a binary overlap score on designated position-pairs, which can be interpreted as a contact-map overlap score in structural applications....

arXiv CS 8d ago

Beyond Generative Decoding: Discriminative Hidden-State Readout from a Native Omni-Modal LLM for Multimodal Sentiment Analysis

arXiv:2606.05713v1 Announce Type: new Abstract: Multimodal sentiment analysis (MSA) infers human affect from language, acoustic, and visual signals. Recent methods increasingly adapt large multimodal models (LMMs) via generative readout: prompting the model to emit a sentiment score as a text string. While convenient, this ties continuous regression to discrete autoregressive decoding, incurring unmeasured costs.

arXiv CS 5d ago

Dynamic Interaction-Aware and Causality-Disentangled Framework for Multimodal Sentiment Analysis

arXiv:2605.30994v1 Announce Type: new Abstract: Although Multimodal Sentiment Analysis (MSA) effectively leverages rich information from language, visual, and acoustic modalities, existing methods still face two core challenges: 1) static conflict suppression mechanisms fail to adapt to dynamic variations across samples, and 2) the inherent sentimental bias within the language modality, which can misguide learning from other modalities, remains entangled. To this end, we propose a Dynamic...

arXiv CS 9d ago

ProtGPT3: an Open-source family of Promptable and Aligned Protein Language Models

Generative protein language models (pLMs) enable exploration of vast sequence spaces for protein design, but reliably controlling generation toward desired functional families remains challenging. While protein generation has broadly followed trends in NLP, two directions remain underexplored: alignment methods that optimize model behavior toward design objectives, and prompting-based control at inference time without fine-tuning. We introduce ProtGPT3, an open-source family of protein...

bioRxiv 2d ago

Sensitivity as a Double-Edged Sword: A Trade-off Between Discriminability and Adversarial Robustness

Announce Type: new Abstract: Modern neural networks are highly susceptible to adversarial perturbations. In this work, we identify that part of this vulnerability stems from the sensitivity of the widely used fully connected (FC) classifiers to such perturbations. In contrast, simple $\ell_2$ distance-based classifiers exhibit significantly greater robustness.

arXiv CS 8d ago

The Unreasonable Redundancy of Nature's Protein Folds

The Unreasonable Redundancy of Nature's Protein Folds Over the last few years, deep neural networks have made generative language modeling dramatically more powerful, giving us large language models. A similar leap happened for continuous modalities like images and videos.

Hacker News 7d ago

Hundreds flee as South Africa anti-migrant mobs go door-to-door

Hundreds flee as South Africa anti-migrant mobs go door-to-door Gansbaai (South Africa) (AFP) – Hundreds of foreigners fearing for their lives have taken shelter in community halls on South Africa's south coast, saying mobs of locals were going door-to-door telling them to leave the country. Issued on: Mostly nationals of Malawi and Mozambique, many told AFP they had fled their homes at the weekend and spent nights in the mountains and bush, before making their way to the small-town...

France 24 7d ago

AMix-1: A Pathway to Test-Time Scalable Protein Foundation Model

arXiv:2507.08920v4 Announce Type: replace-cross Abstract: We introduce AMix-1, a powerful protein foundation model built on Bayesian Flow Networks and empowered by a systematic training methodology, encompassing pretraining scaling laws, emergent capability analysis, in-context learning mechanism, and test-time scaling algorithm. To guarantee robust scalability, we establish a predictive scaling law and reveal the progressive emergence of structural understanding via loss perspective,...

arXiv CS 1d ago

Multi-Segment Attention: Enabling Efficient KV-Cache Management for Faster Large Language Model Serving

Announce Type: new Abstract: Large Language Model (LLM) inference relies on key-value (KV) caches to avoid redundant attention computation. While approximate KV cache retention techniques reduce memory usage by sacrificing model accuracy, lossless approaches instead evict KV cache blocks from GPU memory and reconstruct them on demand to preserve exact outputs. Existing lossless KV cache management systems primarily base eviction decisions on access frequency or positional heuristics, without...

arXiv CS 7d ago