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A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Amplified Arctic iceberg traffic reshapes benthic biodiversity
Abstract The Arctic is undergoing rapid warming, resulting in retreating sea ice and glaciers1, yet how cryospheric changes propagate into the deep ocean remains poorly understood2. Here we identify a climate-driven mechanism linking accelerating glacier disintegration to an increase in deep-sea hard-bottom habitats far beyond calving fronts. Seafloor observations in Fram Strait show a localized increase in the density and patchiness of dropstones delivered by debris-laden icebergs.
Panthers captain Barkov leads Finland past Canada
Finland upset Canada 4-2 and set up the final against Switzerland at the ice hockey world championship on Saturday. Finland is one win away from lifting the trophy for a fifth time and first since 2022. Switzerland is seeking its first title.
‘It can all end with one bad game’: the highs and lows of a World Cup referee
Even the finest miss out on a place at the finals and for those who do get there, decisions can make or break a dreamIsmail Elfath was taking his children to the park near his home in Texas when a message arrived. “Congratulations,” it read. Elfath hugged his wife.
Big 12 preview: Despite the drama, Texas Tech stil...
Back when the NIL era was in its nascent stages, with a new Big 12 and a 12-team College Football Playoff on the way, I wondered if there was room for the emergence of a Clemson-style dynasty from a conference known primarily for the endless number of close games. If some team could craft a recruiting boost from both solid spending and sustained success, perhaps they could ride that to a series of conference titles and, perhaps, even playoff runs? I admittedly didn't have a specific team in...
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.
Code Lifespan Survival Analysis (CLSA): Predicting the Survival of Source Code Lines Using AST-Aware Mining
arXiv:2606.04993v1 Announce Type: new Abstract: Context: Predicting which source lines will be deleted - and when - matters for maintenance, technical debt, and review prioritization. Existing MSR approaches work at file or method granularity, masking individual-statement risk. Objective: We introduce Code Lifespan Survival Analysis (CLSA), the first framework to model code survival at individual-line granularity.
Princess Lilibet must follow one major royal rule in reunion with King Charles
Princess Lilibet must follow one major royal rule in reunion with King Charles With rumours swirling that Prince Harry, Meghan Markle and their children will travel to the UK for an Invictus event, if a reunion with the King is on the cards, Lilibet must abide by one royal protocol After years of living in California after quitting his royal duties, Prince Harry is set to return to the UK in the coming months for an event for the Invictus Games. The Duke of Sussex is expected to visit...
Complex-phase stochastic modeling of mitochondrial heteroplasmy
Mitochondrial heteroplasmy the coexistence of both wild-type and mutant copies of mitochondrial DNA ( mtDNA ) within a cell is a key factor in the pathogenesis of mitochondrial diseases. Classical approaches, which rely solely on the scalar fraction of mutant DNA, fail to fully account for threshold effects, the stochastic nature of heteroplasmy dynamics , and tissue specificity. The aim of the work is to construct a complex stochastic model of heteroplasmy dynamics , which for the first...
Should you send that midnight text? 11 essential rules for phone etiquette
What about using voice notes, or calling someone totally unannounced? Experts give their verdict on how to use your phone without causing offenceIt is not news that many of us are addicted to our phones and nor is it a revelation that inconsiderate public behaviour now appears to be the norm, but when the two collide it can cause anger. Last week, at the end of a performance of the drama Inter Alia in London’s West End, the actor Rosamund Pike took to the stage after the curtain call to...