Mrs N
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Five year old girl was left “traumatised” and in pain after physician assistant wrongly prescribed vaginal pessary
A 5 year old girl in England was left bleeding, traumatised, and screaming with pain after a physician associate (PA; now known as a physician assistant) wrongly prescribed a pessary to treat itching and vaginal discharge, an investigation by the parliamentary and health service ombudsman has found.1Vaginal pessaries should not be used in prepubescent children, but a GP authorised the prescription on the basis of the PA's recommendation, and a pharmacy dispensed the pessary without...
Transcriptionally Active HIV Reservoirs Enriched for Interferon-Inducible APOBEC3-Related Mutational Signatures Associate with Reduced Neuroaxonal Integrity
Despite sustained viral suppression with effective antiretroviral therapy (ART), neuroaxonal integrity persist in a subset of people with HIV-1 (PWH). We investigated whether interferon (IFN)-inducible APOBEC3-associated mutational signatures, reflected by premature stop codons (PSCs), and reservoir-associated drug resistance mutations (RS-DRMs) within transcriptionally active HIV-1 reservoirs influence neuroaxonal integrity in fully virally suppressed individuals. Peripheral CD4 T cells...
Ask HN: What are tools you have made for yourself since the advent of AI?
I've made a number of ceramic molds for slumping fused glass into bowls. As well as wooden templates for ceramic mugs. I've devised a few carrying tools to move glass frit paintings from my studio down to my barn where the kilns sit without spilling the glass.