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Related Articles from SNS
Why diabetes matters in dementia studies. Excluding diabetes status masks regional mitochondrial DNA copy number changes in human hippocampus, amygdala, and cerebellum in Alzheimers disease
Diabetes is a major risk factor for Alzheimers disease (AD), and both diseases involve mitochondrial dysfunction. We hypothesised that AD is associated with reduced mitochondrial DNA copy number (mtDNA-CN) in vulnerable brain regions, and that diabetes modifies these changes. Post mortem hippocampus, amygdala, and cerebellum samples (N=66-77) from non cognitively impaired (NCI) and AD donors, with and without diabetes, were analysed.