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Related Articles from SNS
I was recently diagnosed with anti-NMDA receptor encephalitis
I was recently diagnosed with anti-NMDA receptor encephalitis. It is an autoimmune disorder where your body’s normally helpful antibodies start acting strangely. This leads to inflammation in the brain.
A thalamus–brainstem attractor network drives history-biased decisions
Abstract Natural environments often change gradually, making it adaptive to bias decisions on the basis of the recent past — a phenomenon known as serial dependence1,2,3. Large-scale recordings during behaviour have identified that serial dependence is a common motif for decision-making, with neural representations of past experiences found throughout the brain4,5,6,7,8,9,10,11. However, it remains unclear whether this bias arises from dedicated neural circuits with history-specific...
A Na⁺-PINK1 signaling axis couples mitochondrial fission to structural remodeling during synaptic depression
Mitochondrial density in dendrites adapts to the number of synaptic inputs to adequately sustain local ATP and Ca2+ buffering for neuronal signaling. During long-term depression (LTD), synapse elimination is accompanied by activation of caspase-3 through sublethal mitochondria-derived apoptotic signals, driving neurotransmitter receptor internalization and spine shrinking. However, the upstream signals that link synaptic activity to mitochondrial remodeling remain unknown.
What can a neuron compute
Cortical pyramidal neurons possess elaborate dendritic trees with diverse nonlinear membrane conductances and thousands of plastic synapses, suggesting substantial computational capabilities at the single-cell level. Yet, what can a neuron compute remains an open question, largely due to the lack of a systematic framework to quantify its computational capabilities. We introduce TwinProp, a digital-twin-based backpropagation algorithm that enables gradient-based optimization of synaptic...