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Do AI Structure Predictors Capture Bound-State Disorder? A Benchmark on Fuzzy Protein Complexes

Fuzzy protein complexes, in which an intrinsically disordered protein (IDP) retains conformational disorder upon binding, pose a fundamental challenge for structure predictors trained on ordered systems, where crystal structures capture only the most ordered ensemble snapshot, making standard benchmarking metrics misleading. Here, we present the first systematic evaluation of AlphaFold3 (AF3), AlphaFold2-Multimer (AF2MM), Chai-1, and Boltz-2 on a curated dataset of fuzzy complexes from...

bioRxiv 9d ago

What’s Worth More Than Cash in San Francisco Real Estate? Anthropic Stock

Few things are more valuable in the Bay Area than real estate. In San Francisco, the median house price is now over $2 million. Last month, at least seven houses in the city sold for $1 million over the asking price, and buyers regularly offer to pay in cash or waive contingencies to stay competitive.

Wired 7d ago

The Untold Story of the Google Buses That Took Over San Francisco

Activists in San Francisco’s Mission District weren’t giving up easily. David Campos had taken the baton from Chris Daly as the city Supervisor leading the anti-gentrification advocates, who were anchored in a handful of nonprofit community groups. During the springtime festivities for Cinco de Mayo in 2015, Campos called for a moratorium on all new housing construction in the Mission, saying it was the only way to give the district “a fighting chance.”

Wired 1d ago

Is the GOP Starting to Defy Trump?

Subscribe here: Apple Podcasts | Spotify | YouTube | Overcast | Pocket CastsA couple of weeks ago, several Republican senators not only criticized President Trump’s proposed $1.8 billion “Anti-Weaponization Fund” in a private meeting but “screamed” at Acting Attorney General Todd Blanche, according to Senator Ted Cruz on his podcast. “There were multiple senators yelling at the attorney general, saying this feels like self-dealing,” Cruz said, presumably echoing broader criticism that this...

The Atlantic 6d ago

Lebanon and Israel’s perpetual war machine

Lebanon and Israel’s perpetual war machine Why Lebanon remains central to Israel’s multi-front wars. Plus, AfrofeminasGPT, a chatbot designed to promote more ethical AI. The impasse in the US-Israel war on Iran has turned Lebanon into the conflict’s most active front.

Al Jazeera 4d ago