Notch
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Auranofin potentiates cisplatin response through context-dependent NOTCH-associated signaling states in endometrial cancer
Therapeutic resistance remains a major challenge in advanced and recurrent endometrial cancer (EC). Aberrant NOTCH signaling has been associated with aggressive tumor behavior and therapeutic resistance across multiple malignancies, yet its therapeutic significance in EC remains incompletely defined. We investigated whether auranofin (AuR), a noncanonical modulator of NOTCH signaling through the transcriptional effector RBPJ, alters platinum responsiveness in EC models.
Ramp Notches $44 Billion Valuation in New Funding Round
Eric Glyman, chief executive officer of RAMP, during the 2026 Reagan National Economic Forum at the Ronald Reagan Presidential Library in Simi Valley, California, US, on Friday, May 29, 2026. This year's conversations are expected to focus on growth, opportunity, and the challenges and possibilities ahead for American communities, families, and businesses.
Vinted boss sees 'fundamental' shift in consumer patterns, as secondhand firm notches $9 billion valuation
Online resale app Vinted is seeing a structural shift in consumer behaviour, as habits form around the resale economy, the company's marketplace boss told CNBC on Monday. Vinted, the consumer-to-consumer platform allowing customers to sell unwanted items like clothing, electronics, or even furniture, has seen rapid growth in recent years, boosted by consumers increasingly looking for value amid rising costs of living globally. The value of items sold on Vinted grew nearly 50% last year, as...
About 10,000 cars stolen or broken into in Melbourne each year
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Bitcoin’s sagging price has crypto bears taking a victory lap. Why it’s too soon to count it out.
While U.S. stocks have kept notching record highs, bitcoin is sliding to its weakest level in months.
Brunson stars and Wemby struggles as Knicks take NBA Finals opener on the road
Stuart Hodge NBA Finals: Jalen Brunson stars as New York Knicks beat San Antonio Spurs in Game 1 The New York Knicks took Game 1 on the road as Victor Wembanyama struggled to score in the San Antonio Spurs' NBA Finals opener; Jalen Brunson notched 30 points and provided vital impetus as the visitors came from behind in the fourth quarter Last Updated: 04/06/26 7:30am The New York Knicks raised their NBA Playoffs winning streak to a dozen games as Jalen Brunson starred in their Finals opener...
‘Buying stuff like it’s going out of fashion’: Biotech M&A on track for best year since pre-Covid
Global biopharma M&A is experiencing a sharp uptick, putting the sector on track for its strongest year since the pre-pandemic peak seven years ago. Driven by looming patent cliffs, newly buoyant public markets, and Big Pharma's race to beef up their pipelines, dealmaking so far in 2026 amounted to $106 billion over 201 deals, according to PitchBook data. If the current pace of biopharma M&A holds up for the rest of the year, the industry could be on track to notch more than $250 billion in...
How Iran war allows residents to indulge in opulence at Dubai’s luxury hotels
How Iran war allows residents to indulge in opulence at Dubai’s luxury hotels The lavish hotels, once exclusive to rich visitors, now attract locals with enticing staycation offers amid a tourism slump Once reserved for wealthy travellers, Dubai’s top-notch hotels have become almost exclusively reliant on residents, drawn in by dizzying staycation offers as war drives tourists away. On the Palm, an artificial island that has become synonymous with Dubai opulence, five-star hotels are busy on...
Today on Sky Sports Racing: Kakirra chases hat-trick at Wolverhampton
Today on Sky Sports Racing: Newcastle, Southwell and Wolverhampton feature live on Tuesday Billy Loughnane and Ollie Sangster combine in the Wolverhampton opener with Kakkira who looks to notch up a hat-trick in what looks a potentially trappy affair; we also have competitive action from Newcastle and Southwell, live on Sky Sports Racing from 2.30pm Sunday 31 May 2026 19:27, UK We have a busy day’s racing on Tuesday with action from Newcastle, Southwell and Wolverhampton, live on Sky Sports...